Appalachian Tri-State Node

描述(由申请人提供)：这是NIDA临床试验网络(CTN)的阿巴拉契亚三州(ATS)节点响应RFA-DA-10-009提出的竞争性续签申请。在上一次供资期间，ATS节点为CTN的研究、传播和行政活动作出了重大贡献。我们与NIDA、其他节点和社区治疗提供者(CTP)有效地合作，通过以下方式推进CTN的使命：1)参与四项临床试验并准备第五次临床试验；2)为正在审查的新方案做出贡献；3)为试验编写治疗手册；4)为实验干预开发和提供临床培训方案和保真度量表；5)通过讲座、培训计划、会议、面向专业人员的文章和为有药物问题的患者撰写的文章，传播有关NIDA循证治疗(EBT)的信息；以及6)参与CTN委员会、工作组以及国家和地区传播会议规划委员会。在过去的四年中实施了四项新的CTN试验，ATS是参与所有四项试验的三个CTN节点之一，通过在这些试验中随机选择255名受试者，为四项CTN研究中的三项提供了出色的受试者招募，从而超过了我们最初的招募目标。为了应对NIDA不断变化的研究需求，在非成瘾治疗环境中进行临床试验，ATS节点扩大了我们的CTP，将医疗和精神系统以及艾滋病毒初级保健诊所包括在内。为了展示我们在概念上为未来的CTN项目做出贡献的能力，我们提出了一个研究议程，重点是与精神和/或医学疾病共同发生的物质使用障碍(SUDS)的研究。由于患有其他疾病的人中肥胖症的高患病率，以及缺乏对许多专门的临床人群，特别是在医疗环境中的患者的研究，因此需要对共同发生的医疗和精神健康状况进行研究。潜在的CTN研究可以集中在筛查、识别和参与这些非成瘾环境中的SUDS患者，以及检查干预措施的传播和成本效益。 与公共健康相关：这项资助的应用程序将通过在严格的多地点临床试验中对行为、药理学和综合治疗干预措施进行研究，以确定在广泛的治疗环境和多样化的患者群体中的有效性，并确保将研究结果转移给医生、临床医生、提供者和患者，从而提高全国药物滥用治疗的质量。

DESCRIPTION (provided by applicant): This is a competing renewal application by the Appalachian Tri-State (ATS) Node of NIDA's Clinical Trials Network (CTN) in response to RFA-DA-10-009. During the previous funding period, the ATS Node made substantial contributions to CTN research, dissemination and administrative activities. We collaborated effectively with NIDA, other Nodes and community treatment providers (CTPs) in advancing the mission of the CTN by: 1) participating in four clinical trials and preparing for a fifth; 2) contributing to new protocols under review; 3) writing a treatment manual for a trial; 4) developing and delivering clinical training protocols and fidelity scales for experimental interventions; 5) disseminating information about NIDA Evidenced-Based Treatments (EBTs) through lectures, training programs, conferences, writings for professionals and writings for patients with drug problems; and 6) participating in CTN committees, work groups and national and regional dissemination conference planning committees. Four new CTN trials were implemented during the past 4 years and ATS was one of three CTN Nodes that participated in all four, having excellent subject recruitment for three of four CTN studies by exceeding our original recruitment goals by randomizing 255 subjects in these trials. In response to the changing research needs of NIDA to conduct clinical trials in non-addiction treatment settings, the ATS node expanded our CTPs to include medical and psychiatric systems and an HIV primary care clinic. To demonstrate our ability to contribute conceptually to future CTN projects, we propose a research agenda that focuses on studies of substance use disorders (SUDs) that co-occur with psychiatric and/or medical conditions. Studies of co-occurring medical and mental health conditions are needed because of the high prevalence of SUDs among those who have other illnesses and the lack of studies for many specialized clinical populations, especially patients in medical settings. Potential CTN studies could focus on screening, identifying and engaging patients with SUDs in these non-addiction settings as well as examining dissemination and cost-effectiveness of the interventions. PUBLIC HEALTH RELEVANCE: The funded application will improve the quality of drug abuse treatment throughout the country by conducting studies of behavioral, pharmacological, and integrated treatment interventions in rigorous, multi-site clinical trials to determine effectiveness across a broad range of treatment settings and diversified patient populations; and to ensuring the transfer of research results to physicians, clinicians, providers, and patients.