Biostatistics Core

生物统计学和数据管理（BDM）本计划项目的核心将提供支持和服务， 实验设计，数据管理，数据分析和数学建模的每一个建议 项目我们还将协助起草数据分析报告，并为所有建议的项目准备手稿。 实验和研究。具体目标包括：1）支持研究设计，进行数据分析，准备 分析报告，并协助起草与本研究中所有研究相关的摘要和手稿以供出版。 程序项目; 2）为多参数流式细胞术数据分析提供支持，包括流式细胞术 细胞计数数据门控以鉴定亚群，CFSE标记数据建模/分析以定量细胞 3）为拟采用的技术方案提供数学建模和统计分析服务; 氘在体内标记实验，以确定细胞增殖和动力学的关键参数， 人类受试者; 4）为所提议的项目执行高通量微阵列数据的分析;以及5） 为所有项目和研究提供集中的数据管理服务。为了实现这些目标， BDM核心，我们已经形成了一个经验丰富的团队，由生物统计学家，生物数学， 建模人员和数据管理人员，他们在所有必需的服务中具有各种专业知识。BDM核心成员 将与项目研究人员密切合作，进行实验设计、数据分析和 分析报告和手册。

Biostatistics and Data Management (BDM) Core of this program project will provide support and services for expenmental design, data management, data analysis and mathematical modeling for each of the proposed projects. We will also assist in drafting data analysis reports and preparing manuscripts for all proposed expehments and studies. Specific aims include: 1) Support study design, perform data analysis, prepare analysis reports, and assist in drafting abstracts and manuscripts for publication related to all studies in this program project; 2) Provide support for multi-parameter flow cytometry data analyses that include flow cytometry data gating to identify sub-populations and CFSE labeling data modeling/analysis to quantify cell proliferations; 3) Provide services of mathematical modeling and statistical analysis for the proposed deuterium in vivo labeling expehments to determine key parameters of cell proliferation and kinetics in vivo in human subjects; 4) Perform analysis of high throughput microarray data for the proposed projects; and 5) Provide centralized data management services to all projects and studies. In order to achieve these aims of the BDM Core, we have formed an experienced team consisting of biostatisticians, biomathematical modelers, and data managers with a variety of expertise in all required services. The BDM Core members will closely work with the project investigators in design of experiments, data analysis and preparation of analysis report and manuschpts.