Modeling Immunity for Biodefense

生物防御免疫建模

• 批准号: 8036356
• 负责人: Hulin Wu
• 金额: $ 208.21万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8036356
• 关键词: Biological Models; Categories; Computer Simulation; Computers; Data Analyses; Disease; Engineering; Equilibrium; Foundations; Human; Immune; Immune response; Immunity; Immunology; In Vitro; Infection; Influenza; Influenza A virus; Internet; Knowledge; Laboratories; Measures; Mediating; Modeling; National Institute of Allergy and Infectious Disease; Orthopoxvirus; Simulate; Smallpox; Statistical Methods; Structure; Universities; Vaccination; Vaccinia virus; base; biodefense; design; immune function; improved; in vivo; mathematical model; model development; novel; pathogen; programs; research study; simulation; software systems; user-friendly

The program, Modeling Immunity for Biodefense, will develop novel or improved highly predictive mathematical models that simulate immune function. These model systems will be developed for analysis of host immune responses to NIAID category A-C pathogens, and may apply to other infectious and immune-mediated diseases. Knowledge gained from these studies will: advance our understanding of the delicate balance required to induce protective immunity; guide laboratory experiments of host immune responses; and lay the foundation for development of models that can extrapolate human immune responses to infection or immune-mediated diseases based on results from relevant in vitro and in vivo studies.

该项目名为生物防御免疫建模，将开发新的或改进的高预测数学模型来模拟免疫功能。这些模型系统将用于分析宿主对NIAID A-C类病原体的免疫反应，并可能适用于其他感染性和免疫介导的疾病。从这些研究中获得的知识将：促进我们对诱导保护性免疫所需的微妙平衡的理解；指导宿主免疫应答的实验室实验；并为开发基于相关体外和体内研究结果推断人类对感染或免疫介导疾病的免疫反应的模型奠定基础。