Functional Organization of Auditory Cortex
听觉皮层的功能组织
基本信息
- 批准号:7792373
- 负责人:
- 金额:$ 50.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-04-01 至 2012-04-30
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressAffectAgingAlzheimer&aposs DiseaseAnimal ModelAreaAuditoryAuditory areaAutistic DisorderAutopsyAxonBiteBrainBrain PartCellsClinicalCodeComparative StudyConceptionsDataDimensionsDyslexiaElementsEnzymesEpilepsyEvaluationFoundationsFunctional ImagingFundingGenomicsGoalsGrantHearingHumanInjuryKnowledgeLanguage DelaysLateralLinkMacacaMagnetic ResonanceMagnetic Resonance ImagingMeasurementMedialMemoryMethodsModelingMonkeysNeuronsOperative Surgical ProceduresOpticsOutputPan GenusPathologyPhylogenetic AnalysisPhysiologicalPopulationPrimatesProcessPropertyProteinsResearchSchizophreniaSiteStagingStrokeStructureSurfaceSystemTemporal LobeThalamic NucleiThickTissuesTracerWeightWorkauditory stimulusbasecomparativedensitydesignexperiencehearing impairmentinsightneurofilamentneurophysiologynonhuman primatepatient populationprogramsreceptive fieldrelating to nervous systemresearch studyresponsesoundtumor
项目摘要
DESCRIPTION (provided by applicant): The long-term goal of this research program is a comprehensive description of human auditory cortex organization. What are its structural components and what are their functions? How do these elements work together to produce the perceptual experience of hearing? Underlying current conceptions is a regional (modular) system of organization formed by an interconnected group of cortical areas, but the number of areas involved and their connections are unknown for humans. A testable working model of human auditory cortex has not been developed, even though such models are fundamental to studies of auditory cortex in other species. To establish this model, detailed neuroanatomical analyses will be used to reveal the underlying structures that comprise this part of the brain. Efforts will focus on the planum temporale in the superior temporal lobe, which is thought to be an important region for integrating the neural codes required to perceive and interpret sound. Although often treated as a single area, the planum temporale appears to contain several areas that are anatomically and physiologically distinct. Temporal lobes will be obtained postmortem and processed for marker proteins of neurons, axons, neurofilaments, and key enzymes. Areas will be profiled and compared on the basis several measurements (surface area, cortical thickness, neuron density, optical density). The research will be guided and grounded by comparative studies of other primates, which continue to provide an invaluable foundation for studies of auditory cortex in humans. In addition, parallel studies in monkeys will focus on the connections and neuron response properties in the posterior temporal lobe that correspond to the human planum temporale. The relevance of this research applies broadly to patient populations in which the temporal lobe is involved, and directly supports related areas of research involving both normal and clinical populations. These include: 1) Noninvasive methods to study auditory activity in the human brain (e.g., functional imaging); 2) Neurosurgical planning and assessment of function associated with surgery, injury, or related pathology (e.g., cerebrovascular accidents, tumors); 3) Evaluation of cortical function in clinical populations in which auditory processing or memory is affected (e.g., Alzheimer's, schizophrenia, autism, dyslexia, epilepsy, language delay, hearing impairment, and aging); and 4) Maturational and genomic studies of auditory cortex in normal and clinical populations.
描述(由申请人提供):该研究项目的长期目标是对人类听觉皮层组织的全面描述。它的结构部件有哪些,其作用是什么?这些元素如何协同工作以产生听觉的感知体验?当前概念的基础是由一组相互关联的皮质区域形成的区域(模块化)组织系统,但所涉及区域的数量及其连接对于人类来说是未知的。人类听觉皮层的可测试工作模型尚未开发出来,尽管此类模型是其他物种听觉皮层研究的基础。为了建立这个模型,将使用详细的神经解剖学分析来揭示构成大脑这一部分的基础结构。工作重点将集中在上颞叶的颞平面,该区域被认为是整合感知和解释声音所需的神经代码的重要区域。虽然颞平面经常被视为单个区域,但它似乎包含几个在解剖学和生理学上不同的区域。将在死后获得颞叶并对其进行处理以获取神经元、轴突、神经丝和关键酶的标记蛋白。将根据多项测量(表面积、皮质厚度、神经元密度、光密度)对区域进行分析和比较。该研究将以其他灵长类动物的比较研究为指导和基础,这些研究将继续为人类听觉皮层的研究提供宝贵的基础。此外,对猴子的平行研究将重点关注与人类颞平面相对应的后颞叶的连接和神经元反应特性。这项研究的相关性广泛适用于涉及颞叶的患者群体,并直接支持涉及正常和临床群体的相关研究领域。其中包括:1)研究人脑听觉活动的非侵入性方法(例如功能成像); 2) 神经外科规划和与手术、损伤或相关病理(例如脑血管意外、肿瘤)相关的功能评估; 3) 听觉处理或记忆受到影响的临床人群(例如阿尔茨海默病、精神分裂症、自闭症、阅读障碍、癫痫、语言发育迟缓、听力障碍和衰老)的皮质功能评估; 4) 正常和临床人群听觉皮层的成熟和基因组研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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TROY A. HACKETT其他文献
TROY A. HACKETT的其他文献
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{{ truncateString('TROY A. HACKETT', 18)}}的其他基金
Identification of Cellular Phenotypes in the Auditory Forebrain
听觉前脑细胞表型的鉴定
- 批准号:
9250907 - 财政年份:2016
- 资助金额:
$ 50.29万 - 项目类别:
Identification of Cellular Phenotypes in the Auditory Forebrain
听觉前脑细胞表型的鉴定
- 批准号:
9226042 - 财政年份:2016
- 资助金额:
$ 50.29万 - 项目类别:
Gene Expression During Postnatal Development of the Central Auditory Pathway
中枢听觉通路出生后发育过程中的基因表达
- 批准号:
8595221 - 财政年份:2013
- 资助金额:
$ 50.29万 - 项目类别:
Gene Expression During Postnatal Development of the Central Auditory Pathway
中枢听觉通路出生后发育过程中的基因表达
- 批准号:
8353199 - 财政年份:2013
- 资助金额:
$ 50.29万 - 项目类别:
Neurophysiology and Anatomy of Multisensory Processing
多感觉处理的神经生理学和解剖学
- 批准号:
8063828 - 财政年份:2010
- 资助金额:
$ 50.29万 - 项目类别:
Neurophysiology and Anatomy of Multisensory Processing
多感觉处理的神经生理学和解剖学
- 批准号:
8374406 - 财政年份:2010
- 资助金额:
$ 50.29万 - 项目类别:
Neurophysiology and Anatomy of Multisensory Processing
多感觉处理的神经生理学和解剖学
- 批准号:
8576450 - 财政年份:2010
- 资助金额:
$ 50.29万 - 项目类别:
Neurophysiology and Anatomy of Multisensory Processing
多感觉处理的神经生理学和解剖学
- 批准号:
8196888 - 财政年份:2010
- 资助金额:
$ 50.29万 - 项目类别:
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