Differential odor-response and central-projection patterns of mitral and tufted c
二尖瓣和簇绒 c 的差异气味反应和中心投影模式
基本信息
- 批准号:7882542
- 负责人:
- 金额:$ 14.85万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-01 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptedApicalAreaAuditory systemAxonBiological AssayBrainCalciumCell physiologyCellsCodeColorDataDendritesDextransDyesElectrophysiology (science)ElectroporationEnsureEnvironmentGoalsGrantImageInhibitory SynapseKnowledgeLabelLateral Geniculate BodyLocationMicroscopyModalityMolecularMorphologyMovementNeuronsOdorsOlfactory PathwaysOlfactory tuberclePathway interactionsPatternPopulation ProjectionPresynaptic TerminalsProcessPropertyQuality of lifeRetinaSensorySeriesShapesSignal TransductionSkinSmell PerceptionStimulusSystemTechniquesTestingVertebral columnVisualVisual system structurearea striatabasecomparativecomputerized data processingdextranganglion cellin vivoinsightinterestneural circuitneuromechanismneuronal cell bodyolfactory bulbparallel processingpiriform cortexpreferencepressurepublic health relevanceresearch studyresponsesensory stimulussensory systemsomatosensorytwo-photon
项目摘要
DESCRIPTION (provided by applicant): Parallel processing is a common principle across different sensory systems. The brain tends to encode different aspects of a sensory stimulus into separate projection pathways for carrying out unique processing optimized for dedicated features. Though parallel pathways are well studied in other sensory modalities, it remains unclear how olfactory signals are transmitted to high-order centers through similar parallel-processing circuits. In this grant, I propose to explore this issue by focusing on the two major types of projection neurons in the olfactory bulb, the mitral and tufted cells. While early analyses of neuronal morphology suggest that they may represent two separate pathways for odor processing, their functional distinctions have not yet been well characterized. This is mainly due to the fact that it is difficult to compare the odor-response properties without knowing whether interested neurons receive olfactory inputs from common or different glomeruli. Furthermore, it is not clear whether these cells have different axonal projections into the olfactory tubercle and piriform cortex. To address these two questions, I will take advantage of my recently developed approach, which combines dextran-dye local electroporation and in vivo two-photon calcium imaging to achieve simultaneous tracing of neural circuits and imaging of cellular functions. A systematic comparative analysis will be carried out on the odor response profiles of mitral and tufted cells sharing a common glomerular input, in search for insights into how they are differently involved in coding and processing different odor features. Based on my current preliminary data, I will further test the hypothesis that mitral and tufted cells display different preferences of their axonal termination fields. With these two series of experiments, I expect to ultimately establish, from both the functional and circuitry points of view, that mitral and tufted cells indeed constitute two parallel processing pathways handling different sets of odor information.
Public Health Relevance: All sensory systems essentially provide a parallel interface between our brain and external environment. Neural mechanisms underlying the parallel processing of sensory inputs have already been well studied in the visual and auditory systems. However, for the sense of smell, which contributes critically to our daily life quality, it remains so far poorly understood how such parallel signal-processing mechanisms are implemented in this system, especially at the neuronal-circuit level. I here propose a series of experiments to test the hypothesis that the two major types of principal neurons in the olfactory bulb, the mitral and tufted cells, display quite different odor response profiles and central axonal projection patterns. Such differences enable these neurons to function as the backbone in two parallel odor-processing pathways, which are involved in processing different aspects of odor information.
描述(由申请人提供):并行处理是不同感官系统的共同原理。大脑倾向于将感官刺激的不同方面编码到单独的投射路径中,以执行针对专用功能优化的独特处理。尽管并行通路在其他感觉方式中得到了充分研究,但仍不清楚嗅觉信号如何通过类似的并行处理电路传输到高阶中心。在这笔资助中,我建议通过关注嗅球中两种主要类型的投射神经元(二尖瓣细胞和簇状细胞)来探索这个问题。虽然对神经元形态的早期分析表明它们可能代表两种不同的气味处理途径,但它们的功能区别尚未得到很好的表征。这主要是因为在不知道感兴趣的神经元是否接收来自共同或不同肾小球的嗅觉输入的情况下,很难比较气味反应特性。此外,尚不清楚这些细胞是否具有不同的进入嗅结节和梨状皮层的轴突投射。为了解决这两个问题,我将利用我最近开发的方法,该方法结合了葡聚糖染料局部电穿孔和体内双光子钙成像,以实现神经回路的同步追踪和细胞功能的成像。将对共享共同肾小球输入的二尖瓣和簇状细胞的气味反应谱进行系统的比较分析,以深入了解它们如何以不同的方式参与编码和处理不同的气味特征。根据我目前的初步数据,我将进一步检验二尖瓣和簇状细胞对其轴突终止场表现出不同偏好的假设。通过这两个系列的实验,我希望最终从功能和电路的角度确定二尖瓣和簇状细胞确实构成了处理不同气味信息集的两个并行处理途径。
公共健康相关性:所有感觉系统本质上都在我们的大脑和外部环境之间提供并行接口。感觉输入并行处理背后的神经机制已经在视觉和听觉系统中得到了深入研究。然而,对于对我们日常生活质量至关重要的嗅觉,迄今为止,人们对如何在该系统中实现这种并行信号处理机制(尤其是在神经元电路层面)仍知之甚少。我在这里提出了一系列实验来检验这样的假设:嗅球中两种主要类型的主要神经元,二尖瓣细胞和簇状细胞,显示出完全不同的气味反应特征和中央轴突投影模式。这种差异使这些神经元能够作为两个并行的气味处理途径的骨干,参与处理气味信息的不同方面。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Shin Nagayama其他文献
Shin Nagayama的其他文献
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{{ truncateString('Shin Nagayama', 18)}}的其他基金
Neuronal and Network Dynamics in the Olfactory System
嗅觉系统中的神经元和网络动力学
- 批准号:
8673672 - 财政年份:2014
- 资助金额:
$ 14.85万 - 项目类别:
Neuronal and Network Dynamics in the Olfactory System
嗅觉系统中的神经元和网络动力学
- 批准号:
8827167 - 财政年份:2014
- 资助金额:
$ 14.85万 - 项目类别:
Neuronal and Network Dynamics in the Olfactory System
嗅觉系统中的神经元和网络动力学
- 批准号:
9036994 - 财政年份:2014
- 资助金额:
$ 14.85万 - 项目类别:
Neuronal and Network Dynamics in the Olfactory System
嗅觉系统中的神经元和网络动力学
- 批准号:
9246484 - 财政年份:2014
- 资助金额:
$ 14.85万 - 项目类别:
Differential odor-response and central-projection patterns of mitral and tufted c
二尖瓣和簇绒 c 的差异气味反应和中心投影模式
- 批准号:
7647830 - 财政年份:2009
- 资助金额:
$ 14.85万 - 项目类别:
Differential odor-response and central-projection patterns of mitral and tufted c
二尖瓣和簇绒 c 的差异气味反应和中心投影模式
- 批准号:
8079464 - 财政年份:2009
- 资助金额:
$ 14.85万 - 项目类别:
Optical Imaging of Olfactory Sensory Code Transformation
嗅觉感官代码转换的光学成像
- 批准号:
8089267 - 财政年份:2008
- 资助金额:
$ 14.85万 - 项目类别:
Optical Imaging of Olfactory Sensory Code Transformation
嗅觉感官代码转换的光学成像
- 批准号:
7902133 - 财政年份:2008
- 资助金额:
$ 14.85万 - 项目类别:
Optical Imaging of Olfactory Sensory Code Transformation
嗅觉感官代码转换的光学成像
- 批准号:
8277392 - 财政年份:2008
- 资助金额:
$ 14.85万 - 项目类别:
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