ctsa infrastructure for aids research

ctsa 艾滋病研究基础设施

• 批准号: 8175547
• 负责人: ROBERT M CALIFF
• 金额: $ 9.22万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-09-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8175547
• 关键词: Acquired Immunodeficiency Syndrome; Area; Basic Science; Bioinformatics; Biological Process; Caring; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communities; Duke Comprehensive Cancer Center; Environment; Faculty; Fostering; Funding; Genome; Grant; Healthcare; Home environment; House Staffs; Human Resources; Individual; Informatics; Institutes; Intervention; Laboratories; Leadership; Link; Measurement; Medical; Methods; Modeling; National Center for Research Resources; Nursing Schools; Outcome; Patients; Pediatric Research; Population; Public Health; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; School Nursing; Schools; Science Policy; Students; Training; Translating; Translational Research; Universities; bench to bedside; career; cost; design; graduate student; health care delivery; improved; novel; programs; success

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. Duke proposes to create a Clinical Translational Science Institute (CTSI). This institute will accomplish four specific aims: 1) To create an institute that will transform how fundamental discoveries are translated into improved medical care by supporting creative translational research teams. The institute will provide leadership and resources for original translational and clinical research, and it will develop and perform studies regarding novel methods and approaches to translational and clinical science. 2) Create an environment in which trainees at all levels, including medical and nursing school students, physical therapists, pharmacologists, house staff, fellows, graduate students, junior faculty and career transition faculty can be trained in translational and clinical research. The training will be built on the principle that a rich clinical and translational research environment will provide Duke trainees with models and opportunities for success. 3) Integrate translational and clinical science by fostering collaboration among Duke's departments, institutes, centers, and schools using human resources supported by modern bioinformatics and a new clinical research unit designed to integrate intensive measurements of biological processes. 4), Develop a community model for understanding how to translate the findings of research from bench to bedside to populations using advanced informatics and health services delivery methods. The Duke CTSI will be founded on three entities, or pillars, including the Duke Translational Research Institute (DTRI), the Duke Clinical Research Institute (DCRI), and the Duke Center for Community Research (DCCR). These three entities will bring together and expand existing programs, and will be designed to emphasize the continuities along the spectrum of research that begins in a basic science laboratory and concludes with novel therapies that change outcomes for individual patients. These three pillars (DCRI, DTRI, and DCCR) will be administratively joined into the new Duke Clinical and Translational Science Institute (Duke CTSI), the core of this application. This new institute will link With other key programs, including the Duke Comprehensive Cancer Center, the Duke University School of Nursing, and the Duke Institute for Genome Sciences and Policy, to create a comprehensive home for clinical and translational researchers. The creation of the CTSI is patricianly relevant to public health as it will create an environment that will foster speedier delivery of new interventions and healthcare practices to the community.

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 杜克大学提议创建一家临床转化科学研究所(CTSI)。该研究所将实现四个具体目标：1)创建一个研究所，通过支持创造性的翻译研究团队，将基本发现转化为改善医疗保健的方式。该研究所将为原创的翻译和临床研究提供领导和资源，并将开发和执行关于翻译和临床科学的新方法和途径的研究。2)创造一种环境，使各级受训人员，包括医学院和护理学院的学生、物理治疗师、药剂师、院务人员、研究员、研究生、初级教员和职业过渡教员，都可以接受翻译和临床研究方面的培训。培训将建立在这样一个原则上，即丰富的临床和转化性研究环境将为杜克大学的学员提供成功的模式和机会。3)通过利用现代生物信息学支持的人力资源和一个旨在整合生物过程密集测量的新临床研究单位，促进杜克大学各部门、研究所、中心和学校之间的合作，将翻译科学和临床科学整合起来。4)，开发一个社区模型，以了解如何利用先进的信息学和卫生服务提供方法将研究结果从工作台转化到床边的人群。杜克大学CTSI将建立在三个实体或支柱上，包括杜克翻译研究所(DTRI)、杜克临床研究所(DCRI)和杜克社区研究中心(DCCR)。这三个实体将结合并扩展现有的项目，旨在强调从基础科学实验室开始并以改变个别患者结果的新疗法结束的研究光谱的连续性。这三个支柱(DCRI、DTRI和DCCR)将在管理上合并为新的杜克临床和转化科学研究所(Duke CTSI)，该研究所是该应用程序的核心。这个新的研究所将与包括杜克综合癌症中心、杜克大学护理学院和杜克基因组科学与政策研究所在内的其他关键项目联系起来，为临床和翻译研究人员创建一个综合之家。CTSI的创建与公共卫生密切相关，因为它将创造一种环境，促进向社区更快地提供新的干预措施和医疗保健做法。