Duke CTSA

杜克大学CTSA

• 批准号: 8467106
• 负责人: ROBERT M CALIFF
• 金额: $ 17.98万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2013-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8467106
• 关键词: Biological; Child health care; Clinical; Clinical Research; Collaborations; Communities; Continuing Education; County; Data; Disease; Effectiveness; Electronics; Elements; Evaluation; Fostering; Funding; Future; Generations; Genomics; Grant; Health; Health Services Research; Health system; Healthcare Systems; Home environment; Human; Institutes; Instruction; Investigation; Joints; Learning; Link; Measurable; Medical; Medicine; Methods; Mission; Modification; Molecular Analysis; Outcome; Output; Phase; Pilot Projects; Population; Research; Research Personnel; Research Project Grants; Resources; System; Systems Biology; Technology; Training; Training and Education; Translational Research; Translations; United States National Institutes of Health; Work; base; biomedical informatics; care delivery; career development; clinical application; comparative effectiveness; effectiveness research; experience; flexibility; global health; improved; innovation; meetings; next generation; novel; public-private partnership; skills; social; tool; translational medicine

PROJECT SUMMARY (See instructions): The mission of the Duke Translational Medicine Institute (DTMI) is to catalyze translation across the continuum from scientific discovery to clinical research to care delivery and global health. We propose to fulfill this mission by achieving four Specific Aims:1) Implement the next phase of the clinical and translational research at Duke, by enhancing its scope, its operational effectiveness, and the number of researchers it serves; 2) Provide DTMI investigators with biomedical informatics tools and methods needed to enhance the operational effectiveness of this next phase of the DTMI; 3) Train the next generation of clinical and translational research leaders and support continuing education to enhance the skills of the current generation of research leaders; 4) Develop methods and approaches for integrating research results into practice and practice outcomes into research. While we succeeded in building a home for clinical and translational researchers in the first funding cycle of the CTSA grant, recent discussions at the NIH and our own assessments have pointed out the need for further transformation of the system. Major emphasis must be placed on measurable output, project management, enterprise portfolio management, and public-private partnerships. These themes were reflected in the work of the DTMI during our first five years, and we are prepared to accelerate this effort by: implementing innovative approaches to pilot projects, creating a translational technology resource network, and supporting novel methods. A global proof of concept network to study human systems biology is a key element of DTMI. All human research projects in Duke Medicine (over 4,100) will be coordinated within the same electronic management system. Innovative elements of the plan include novel public private partnerships, a highly developed project management system, and an innovative approach to integration of medical, financial, operational, environmental, and social data into a geospatially referenced enterprise data warehouse. This powerful system, combined with tools that enable use of the data in concert with the community, has enabled the planning for a county-wide effort to improve health outcomes while enabling health services research and joint investigation of biological, medical, and social causes of health and disease. Special emphasis will be placed on integration of child health and comparative effectiveness research into DTMI, as well as on health studies that foster both community engagement and analysis of molecular and genomic data in populations. The flexible DTMI approach emphasizes constant evaluation and modifications based on a detailed continuous improvement paradigm.

项目摘要(见说明)：杜克转化医学研究所(DTMI)的使命是促进从科学发现到临床研究再到医疗服务和全球健康的整个过程的转化。我们建议通过实现四个具体目标来完成这一使命：1)实施杜克大学下一阶段的临床和转化性研究，扩大其范围、操作有效性和服务的研究人员数量；2)为DTMI研究人员提供所需的生物医学信息学工具和方法，以增强这一下一阶段DTMI的操作有效性；3)培训下一代临床和转化性研究领导者并支持继续教育，以提高当代研究领导者的技能；4)开发将研究成果整合到实践中的方法和方法，并将实践成果整合到研究中。虽然我们在CTSA赠款的第一个资助周期成功地为临床和翻译研究人员建立了一个家园，但NIH最近的讨论和我们自己的评估指出了进一步改造该系统的必要性。必须把重点放在可衡量的产出、项目管理、企业投资组合管理和公私伙伴关系上。这些主题反映在DTMI头五年的工作中，我们准备通过以下方式加快这一努力：对试点项目采取创新办法，创建翻译技术资源网络，并支持新方法。一个研究人类系统生物学的全球概念验证网络是DTMI的关键要素。杜克大学医学研究所的所有人类研究项目(超过4100个)将在同一电子管理系统内协调。该计划的创新要素包括新颖的公私伙伴关系、高度发达的项目管理系统，以及将医疗、财务、运营、环境和社会数据整合到地理空间参照的企业数据仓库的创新方法。这一强大的系统与能够与社区协调使用数据的工具相结合，使得能够规划全县范围内的努力，以改善健康结果，同时使卫生服务研究和对健康和疾病的生物、医学和社会原因的联合调查成为可能。将特别重视将儿童健康和比较有效性研究纳入DTMI，以及促进社区参与和对人口中的分子和基因组数据进行分析的健康研究。灵活的DTMI方法强调基于详细的持续改进范例的持续评估和修改。