Duke CTSA

杜克大学CTSA

• 批准号: 8467106
• 负责人: ROBERT M CALIFF
• 金额: $ 17.98万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2013-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8467106
• 关键词: Biological; Child health care; Clinical; Clinical Research; Collaborations; Communities; Continuing Education; County; Data; Disease; Effectiveness; Electronics; Elements; Evaluation; Fostering; Funding; Future; Generations; Genomics; Grant; Health; Health Services Research; Health system; Healthcare Systems; Home environment; Human; Institutes; Instruction; Investigation; Joints; Learning; Link; Measurable; Medical; Medicine; Methods; Mission; Modification; Molecular Analysis; Outcome; Output; Phase; Pilot Projects; Population; Research; Research Personnel; Research Project Grants; Resources; System; Systems Biology; Technology; Training; Training and Education; Translational Research; Translations; United States National Institutes of Health; Work; base; biomedical informatics; care delivery; career development; clinical application; comparative effectiveness; effectiveness research; experience; flexibility; global health; improved; innovation; meetings; next generation; novel; public-private partnership; skills; social; tool; translational medicine

PROJECT SUMMARY (See instructions): The mission of the Duke Translational Medicine Institute (DTMI) is to catalyze translation across the continuum from scientific discovery to clinical research to care delivery and global health. We propose to fulfill this mission by achieving four Specific Aims:1) Implement the next phase of the clinical and translational research at Duke, by enhancing its scope, its operational effectiveness, and the number of researchers it serves; 2) Provide DTMI investigators with biomedical informatics tools and methods needed to enhance the operational effectiveness of this next phase of the DTMI; 3) Train the next generation of clinical and translational research leaders and support continuing education to enhance the skills of the current generation of research leaders; 4) Develop methods and approaches for integrating research results into practice and practice outcomes into research. While we succeeded in building a home for clinical and translational researchers in the first funding cycle of the CTSA grant, recent discussions at the NIH and our own assessments have pointed out the need for further transformation of the system. Major emphasis must be placed on measurable output, project management, enterprise portfolio management, and public-private partnerships. These themes were reflected in the work of the DTMI during our first five years, and we are prepared to accelerate this effort by: implementing innovative approaches to pilot projects, creating a translational technology resource network, and supporting novel methods. A global proof of concept network to study human systems biology is a key element of DTMI. All human research projects in Duke Medicine (over 4,100) will be coordinated within the same electronic management system. Innovative elements of the plan include novel public private partnerships, a highly developed project management system, and an innovative approach to integration of medical, financial, operational, environmental, and social data into a geospatially referenced enterprise data warehouse. This powerful system, combined with tools that enable use of the data in concert with the community, has enabled the planning for a county-wide effort to improve health outcomes while enabling health services research and joint investigation of biological, medical, and social causes of health and disease. Special emphasis will be placed on integration of child health and comparative effectiveness research into DTMI, as well as on health studies that foster both community engagement and analysis of molecular and genomic data in populations. The flexible DTMI approach emphasizes constant evaluation and modifications based on a detailed continuous improvement paradigm.

项目摘要（见说明）：杜克转化医学研究所（DTMI）的使命是促进从科学发现到临床研究再到护理服务和全球健康的连续体的转化。我们建议通过实现四个具体目标来完成这一使命：1）通过扩大其范围，提高其运营效率和服务的研究人员数量，在杜克实施下一阶段的临床和转化研究; 2）为DTMI研究人员提供生物医学信息学工具和方法，以提高DTMI下一阶段的运营效率; 3）培养下一代临床和转化研究领导者，并支持继续教育，以提高当代研究领导者的技能; 4）制定将研究成果纳入实践和将实践成果纳入研究的方法和途径。虽然我们在CTSA资助的第一个资助周期中成功地为临床和转化研究人员建立了一个家，但NIH最近的讨论和我们自己的评估指出，需要进一步改造该系统。主要重点必须放在可衡量的产出、项目管理、企业组合管理和公私伙伴关系上。这些主题反映在DTMI前五年的工作中，我们准备通过以下方式加快这一努力：实施创新方法进行试点项目，创建转化技术资源网络，并支持新方法。研究人类系统生物学的全球概念验证网络是DTMI的关键要素。杜克医学的所有人类研究项目（超过4,100个）将在同一个电子管理系统中进行协调。该计划的创新要素包括新颖的公私伙伴关系，高度发达的项目管理系统，以及将医疗，金融，运营，环境和社会数据整合到地理空间参考企业数据仓库的创新方法。这一强大的系统，加上能够与社区一起使用数据的工具，使规划能够在全国范围内努力改善健康结果，同时使卫生服务研究和联合调查健康和疾病的生物、医学和社会原因成为可能。将特别强调将儿童健康和比较有效性研究整合到DTMI中，以及促进社区参与和人群分子和基因组数据分析的健康研究。灵活的DTMI方法强调基于详细的持续改进范例的不断评估和修改。