CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 基础设施走向这一领域的研究，而不是直接提供资金， 向子项目或子项目工作人员提供NCRR补助金。 尽管我们对人类疾病基本机制的理解取得了爆炸性的进展，但将这些知识转化为治疗和预防疾病的有意义的工作进展缓慢。为了加快基础科学发现服务于患者和社区健康的步伐，我们打算在加州大学弗朗西斯科分校（UCSF）建立临床和转化科学研究所（CTSI）。它的使命将是建立一个全面、综合的 学术家，促进研究和教育的临床和转化科学在加州大学旧金山分校，在附属机构，并在参与社区。其目标是：（1）支持、加强和整合现有的培训计划，增加来自不同学科的受训人员数量，提高他们在临床和转化研究方法方面的培训质量;（2）支持， 改善和整合现有基础设施，以加强临床和转化研究的设计和实施，促进合作，以实现多样化的高质量原创研究;（3）通过提供指导和促进原创研究的机会，并通过改变学术文化， 适当奖励多学科的合作工作;（4）创建一个“虚拟之家”，提供现代通信以简化合作，为开展创新研究提供最佳信息学矩阵，并培养临床和转化科学的发展。 为了实现这些目标，UCSF正在转变其临床和转化研究组织， 建立13个相互关联的方案，提供所需的培训、服务和机会。 这些项目由来自不同学科的高级科学家领导：牙科、医学、护理和药学及其研究生部。的 这些计划反映了来自整个社区的200多名感兴趣、精力充沛和坚定的参与者的意见，其中包括加州大学旧金山分校的大多数学术领袖。这些人员通力合作，确保CTSI的设计和计划实施具有包容性、透明度和灵活性。四所学校（13 368 750美元）和校长办公室（19 186 613美元）为CTSI的愿景提供了大量财政承诺。我们认为这 新能源和资源的注入将为创新研究创造和维持一个丰富的环境，并推动UCSF实现教育和支持临床和转化科学家工作的全部潜力。如果是这样，生物医学将得到发展，我们的病人和社区的健康将受益。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. Despite explosive gains in our understanding of the basic mechanisms of human disease, meaningful translation of this knowledge to the treatment and prevention of disease has moved slowly. To accelerate the pace at which- discoveries in basic science can serve the health of our patients and community, we intend to establish a Clinical and Translational Science Institute (CTSI) at the University of California, San Francisco (UCSF).' Its mission will be to create a comprehensive, integrated academic home that promotes research and education in clinical and translational science at UCSF, at affiliated institutions, and in participating communities. Its goals are: (1) to support, enhance, and integrate existing training programs, increasing the number of trainees from diverse disciplines and improving the quality of their training in clinical and translational research methods; (2) to support, improve, and integrate existing infrastructure to enhance the design and implementation of clinical and translational studies, fostering collaborations to achieve a diverse spectrum of high quality, original research; (3) to enhance career development of clinical and translational researchers by providing mentoring and opportunities to catalyze original research and by changing the academic culture to appropriately reward multidisciplinary collaborative work; (4) to create a "Virtual Home" providing contemporary communications to simplify collaboration, to provide an optimal informatics matrix for conducting innovative research, and to nurture the growth of clinical and translational science. To reach these- goals, UCSF is transforming its clinical and translational research organization to establish 13 interrelated programs that will provide the training, services, and opportunities needed. These programs are led by senior scientists drawn from diverse disciplines:in each of UCSF's four health science schoolsDentistry, Medicine, Nursing, and Pharmacyand its Graduate Division. The plans reflect input from more than 200 interested, energetic, and committed participants from .throughout the community, including most of UCSF's academic leaders. These individuals worked collaboratively to ensure inclusion, transparency, and flexibility in the design and planned implementation of the CTSI. A significant financial commitment to the CTSI vision has been provided by the four schools ($13,368,750) and by the Chancellor's Office ($19,186,613). We believe that this infusion of new energy and resources will create and sustain a rich environment for innovative research and drive the realization of UCSF's full potential to educate and to support the work of clinical and translational scientists. If so, biomedicine will be advanced and the health of our patients and the community will benefit.