Neural Correlates of visual perception and behaviour: Analysis of multiple single-neuron recordings in humans

视觉感知和行为的神经关联:人类多个单神经元记录的分析

基本信息

  • 批准号:
    G0701038/1
  • 负责人:
  • 金额:
    $ 53.38万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2008
  • 资助国家:
    英国
  • 起止时间:
    2008 至 无数据
  • 项目状态:
    已结题

项目摘要

Patients suffering from severe epilepsy that do not improve with medication may be considered for a surgical intervention to remove the seizure originating area. Based on clinical criteria, these patients may be implanted with intracranial electrodes to accurately localize the focus of the seizures and evaluate the potential outcome of the surgery. Since recently, a setup unique in Europe is in place at King?s College London that from the intracranial electrodes allows not only the recording of EEG but also of multiple single-neurons. From the activity of these neurons, we plan to study whether it is possible to predict the onset of epileptic seizures. This has large clinical potential to develop seizure-warning devices or closed loop systems that can preclude the onset of the impending seizures (e.g. using a fast-acting drug or microstimulation). Previous studies at this respect have been inconclusive because they used EEG recordings, which have inherent major limitations due to their poor spatial resolution and high complexity. This will be the first time that such study is done using the activity of single cells.Besides its clinical importance, the recording setup at King?s College London allows the unique opportunity to record directly the activity of single neurons in awake and behaving human subjects, who can report and give details of their perception and behaviour in different tasks and brain states. Using simple experimental paradigms, we plan to address one of the most fascinating and puzzling questions in neuroscience: how do neurons in the brain represent conscious visual perception? For this, we will study the activity of neurons while the subjects see different pictures. Then we will evaluate whether the neurons increase their firing in response to particular pictures and whether these responses change if the pictures are recognized or not.
患有严重癫痫的患者,如果用药后病情没有改善,可以考虑进行手术干预,以移除癫痫的起始区。根据临床标准,这些患者可以植入颅内电极,以准确定位癫痫发作的部位,并评估手术的潜在结果。最近,伦敦S国王学院建立了一种在欧洲独一无二的装置,这种装置不仅可以记录脑电,还可以记录多个单神经元。根据这些神经元的活动,我们计划研究是否有可能预测癫痫发作的发生。这具有很大的临床潜力,可以开发癫痫警报装置或闭合循环系统,以防止即将发生的癫痫发作(例如,使用速效药物或微刺激)。以前在这方面的研究一直没有定论,因为他们使用的是脑电记录,由于其较低的空间分辨率和较高的复杂性,其固有的主要局限性。这将是第一次使用单细胞活动进行此类研究。除了临床重要性,伦敦S国王学院的记录装置提供了一个独特的机会,可以直接记录清醒和行为正常的人类受试者的单个神经元的活动,这些受试者可以报告并提供他们在不同任务和大脑状态下的感知和行为的细节。使用简单的实验范式,我们计划解决神经科学中最吸引人和最令人困惑的问题之一:大脑中的神经元如何代表有意识的视觉感知?为此,我们将研究受试者看到不同图片时神经元的活动。然后,我们将评估神经元是否会对特定的图片做出反应,以及如果图片被识别或不被识别,这些反应是否会发生变化。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Rodrigo Quian Quiroga其他文献

A new approach to quantify information in real-life, complex neuroscience processes. Comment on “Kinematic coding: Measuring information in naturalistic behavior” by Becchio, Pullar, Scaliti and Panzeri
一种量化现实生活中复杂神经科学过程中信息的新方法。对 Becchio、Pullar、Scaliti 和 Panzeri 所著“运动编码:测量自然行为中的信息”的评论
  • DOI:
    10.1016/j.plrev.2025.03.014
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    14.300
  • 作者:
    Ana Sanchez Jimenez;Enrique Fernández Serra;Rodrigo Quian Quiroga
  • 通讯作者:
    Rodrigo Quian Quiroga
Recent Developments in the study of concealed memory detection using physiological and behavioral methods
  • DOI:
    10.1016/j.ijpsycho.2016.07.105
  • 发表时间:
    2016-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Rodrigo Quian Quiroga
  • 通讯作者:
    Rodrigo Quian Quiroga
Concept cells
  • DOI:
    10.1016/j.ijpsycho.2016.07.104
  • 发表时间:
    2016-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Rodrigo Quian Quiroga
  • 通讯作者:
    Rodrigo Quian Quiroga
Lack of context modulation in human single neuron responses in the medial temporal lobe
内侧颞叶中人类单个神经元反应中缺乏情境调制
  • DOI:
    10.1016/j.celrep.2024.115218
  • 发表时间:
    2025-01-28
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Hernan G. Rey;Theofanis I. Panagiotaropoulos;Lorenzo Gutierrez;Fernando J. Chaure;Alejandro Nasimbera;Santiago Cordisco;Fabian Nishida;Antonio Valentin;Gonzalo Alarcon;Mark P. Richardson;Silvia Kochen;Rodrigo Quian Quiroga
  • 通讯作者:
    Rodrigo Quian Quiroga
Erratum to: Bayes optimal template matching for spike sorting – combining fisher discriminant analysis with optimal filtering
  • DOI:
    10.1007/s10827-015-0555-7
  • 发表时间:
    2015-04-15
  • 期刊:
  • 影响因子:
    2.000
  • 作者:
    Felix Franke;Rodrigo Quian Quiroga;Andreas Hierlemann;Klaus Obermayer
  • 通讯作者:
    Klaus Obermayer

Rodrigo Quian Quiroga的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Rodrigo Quian Quiroga', 18)}}的其他基金

Memory formation in the human medial temporal lobe
人类内侧颞叶的记忆形成
  • 批准号:
    BB/T001291/1
  • 财政年份:
    2020
  • 资助金额:
    $ 53.38万
  • 项目类别:
    Research Grant
Visual Perception in Arts and Neuroscience
艺术和神经科学中的视觉感知
  • 批准号:
    AH/I026065/1
  • 财政年份:
    2011
  • 资助金额:
    $ 53.38万
  • 项目类别:
    Research Grant
Ultra Low Power Implantable Platform for Next Generation Neural Interfaces
用于下一代神经接口的超低功耗植入平台
  • 批准号:
    EP/H051651/1
  • 财政年份:
    2011
  • 资助金额:
    $ 53.38万
  • 项目类别:
    Research Grant
Data Reduction Techniques for Systematic Information Quantification in Large Scale, Multiple Spike Trains
大规模、多尖峰序列系统信息量化的数据缩减技术
  • 批准号:
    EP/E057152/1
  • 财政年份:
    2007
  • 资助金额:
    $ 53.38万
  • 项目类别:
    Research Grant
Neural coding of visual inputs in the human medial temporal lobe
人类内侧颞叶视觉输入的神经编码
  • 批准号:
    EP/D052254/1
  • 财政年份:
    2006
  • 资助金额:
    $ 53.38万
  • 项目类别:
    Research Grant

相似海外基金

An electroencephalography study of the neural correlates of visual habituation in infants with hearing loss
听力损失婴儿视觉习惯神经相关性的脑电图研究
  • 批准号:
    ES/X001946/1
  • 财政年份:
    2024
  • 资助金额:
    $ 53.38万
  • 项目类别:
    Research Grant
Development of the emergent process of visual consciousness and neural correlates of consciousness.
视觉意识的涌现过程和意识的神经相关性的发展。
  • 批准号:
    22KJ1906
  • 财政年份:
    2023
  • 资助金额:
    $ 53.38万
  • 项目类别:
    Grant-in-Aid for JSPS Fellows
Neural Correlates of Auditory, Visual, and Audiovisual Motion Perception in Macaque Extrastriate Cortex
猕猴纹状体外皮层听觉、视觉和视听运动知觉的神经相关性
  • 批准号:
    10751148
  • 财政年份:
    2023
  • 资助金额:
    $ 53.38万
  • 项目类别:
Behavioral and Neural Correlates of Deficits in Naturalistic Visual and Auditory Social Cognition in Individuals at Clinical High-Risk for Schizophrenia
精神分裂症临床高危个体自然视觉和听觉社会认知缺陷的行为和神经相关性
  • 批准号:
    10251346
  • 财政年份:
    2020
  • 资助金额:
    $ 53.38万
  • 项目类别:
Neural and neurochemical correlates of metacognition impairment in opioid addiction
阿片类药物成瘾元认知障碍的神经和神经化学相关性
  • 批准号:
    9890580
  • 财政年份:
    2020
  • 资助金额:
    $ 53.38万
  • 项目类别:
Behavioral and Neural Correlates of Deficits in Naturalistic Visual and Auditory Social Cognition in Individuals at Clinical High-Risk for Schizophrenia
精神分裂症临床高危个体自然视觉和听觉社会认知缺陷的行为和神经相关性
  • 批准号:
    10459498
  • 财政年份:
    2020
  • 资助金额:
    $ 53.38万
  • 项目类别:
Hippocampal Neural Correlates of Memory Enhancement Via Theta-Rhythmic Human Brain Stimulation Via Simultaneous TMS/fMRI
通过同步 TMS/fMRI 进行 Theta 节律人脑刺激,海马神经与记忆增强的相关性
  • 批准号:
    9911852
  • 财政年份:
    2019
  • 资助金额:
    $ 53.38万
  • 项目类别:
Individual Differences in Neural Correlates of Selective Attention within a DiverseAttention Population
多样化注意力人群中选择性注意力神经相关性的个体差异
  • 批准号:
    10246784
  • 财政年份:
    2019
  • 资助金额:
    $ 53.38万
  • 项目类别:
Individual Differences in Neural Correlates of Selective Attention within a DiverseAttention Population
多样化注意力人群中选择性注意力神经相关性的个体差异
  • 批准号:
    9916518
  • 财政年份:
    2019
  • 资助金额:
    $ 53.38万
  • 项目类别:
Underlying neural correlates of sex differences in visual cognition
视觉认知性别差异的潜在神经相关性
  • 批准号:
    536998-2018
  • 财政年份:
    2018
  • 资助金额:
    $ 53.38万
  • 项目类别:
    University Undergraduate Student Research Awards
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了