Regulation of translation of human immunodeficiency virus type-1 RNA by the viral Gag protein

我们正在研究人类免疫缺陷病毒(HIV)生命周期的一部分，以了解该病毒如何为新的感染颗粒制造蛋白质。这一点很重要，因为它可能有助于发现抗艾滋病毒治疗的新目标。全世界有超过4000万人感染艾滋病毒，每年有300万人死于与艾滋病有关的疾病。尽管开发了可以延缓艾滋病发作的药物，但对当前药物的抗药性是常见的，而且还没有治愈方法。需要新的治疗方法，需要更多关于艾滋病毒生命周期的知识。生命周期中我们感兴趣的一个领域是病毒如何制造其蛋白质。HIV使用细胞的机械来完成这一任务，但目前尚不清楚该病毒如何能够与正常的细胞蛋白生产竞争。这个研究项目的目的是研究HIV如何与细胞的机制相互作用以促进病毒蛋白的产生，并看看当我们破坏这种相互作用时病毒会发生什么。我们希望，这项研究的结果可能会为HIV生命周期的一个新领域提供药物治疗的靶点。

We are studying part of the life cycle of human immunodeficiency virus (HIV) to understand how the virus makes the proteins for new infectious particles. This is important as it may help to uncover new targets for anti-HIV therapy.More than forty million people worldwide are infected with HIV, and 3 million people die of AIDS-related illnesses every year. Despite the development of drugs which can delay the onset of AIDS, resistance to the current drugs is common, and there is no cure. New therapies are needed, requiring more knowledge about the HIV life cycle.One area of the life cycle that we are interested in is how the virus makes its proteins. HIV uses the cell’s machinery to do this, but it is not known how the virus is able to compete with normal cell protein production. The purpose of this research project is to investigate how HIV interacts with the cell’s machinery to promote viral protein production, and to see what happens to the virus when we disrupt this interaction. We hope that the results of this research may suggest a new area of the HIV life cycle to target with drug therapy.