Regulation of translation of human immunodeficiency virus type-1 RNA by the viral Gag protein

病毒 Gag 蛋白对人类免疫缺陷病毒 1 型 RNA 翻译的调节

• 批准号: G0701220/1
• 负责人: Emma Anderson
• 金额: $ 44.06万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701220%2F1
• 关键词: Regulation; translation; human; immunodeficiency; virus

We are studying part of the life cycle of human immunodeficiency virus (HIV) to understand how the virus makes the proteins for new infectious particles. This is important as it may help to uncover new targets for anti-HIV therapy.More than forty million people worldwide are infected with HIV, and 3 million people die of AIDS-related illnesses every year. Despite the development of drugs which can delay the onset of AIDS, resistance to the current drugs is common, and there is no cure. New therapies are needed, requiring more knowledge about the HIV life cycle.One area of the life cycle that we are interested in is how the virus makes its proteins. HIV uses the cell’s machinery to do this, but it is not known how the virus is able to compete with normal cell protein production. The purpose of this research project is to investigate how HIV interacts with the cell’s machinery to promote viral protein production, and to see what happens to the virus when we disrupt this interaction. We hope that the results of this research may suggest a new area of the HIV life cycle to target with drug therapy.

我们正在研究人类免疫缺陷病毒（HIV）生命周期的一部分，以了解病毒如何为新的感染性颗粒制造蛋白质。这很重要，因为它可能有助于发现抗艾滋病毒治疗的新靶点。全世界有4千多万人感染了艾滋病毒，每年有300万人死于与艾滋病有关的疾病。尽管开发了可以延缓艾滋病发病的药物，但对现有药物的耐药性很常见，而且没有治愈方法。我们需要新的治疗方法，这需要更多关于艾滋病毒生命周期的知识。我们感兴趣的生命周期的一个领域是病毒如何制造蛋白质。HIV利用细胞的机制来做到这一点，但目前尚不清楚这种病毒如何能够与正常细胞的蛋白质生产竞争。这个研究项目的目的是研究HIV如何与细胞机制相互作用以促进病毒蛋白的产生，并观察当我们破坏这种相互作用时病毒会发生什么。我们希望这项研究的结果可以为药物治疗提供HIV生命周期的新领域。