Improved neuroelectrode characteristics using nanomaterials

使用纳米材料改善神经电极特性

• 批准号: 7911972
• 负责人: Edward Wesley Keefer
• 金额: $ 6.45万
• 依托单位: PLEXON, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7911972
• 关键词: Active Sites; Bathing; Businesses; Capital; Carbon; Carbon Nanotubes; Characteristics; Charge; Chemicals; Clinical; Communication; Communities; Coupling; Data; Deposition; Development; Diagnostic radiologic examination; Dystonia; Electric Capacitance; Electric Stimulation; Electrochemistry; Electrodes; Electrolytes; Electron Beam; Electron Microscopy; Elements; Equipment; Evaluation; Funding; Gold; Government; Grant; Hearing; Implanted Electrodes; Life; Marketing; Measures; Metals; Methods; Microelectrodes; Modeling; Modification; Morphology; Muscle; Nervous system structure; Neurons; Oxidation-Reduction; Parkinson Disease; Patients; Performance; Persons; Polymers; Positioning Attribute; Process; Property; Prosthesis; Protocols documentation; Quality of life; Research; Risk; Roentgen Rays; Scanning Electron Microscopy; Services; Small Business Innovation Research Grant; Sonication; Specimen; Spectrum Analysis; Stainless Steel; Stimulus; Stress; Surface; Techniques; Texas; Time; Tissues; Tungsten; Universities; Vision; X ray spectroscopy; base; brain machine interface; chronic pain; electric impedance; improved; interfacial; nanomaterials; nanoscale; neural prosthesis; novel; physical abuse; public health relevance; relating to nervous system; tool

DESCRIPTION (provided by applicant): Plexon Inc will coat the active sites of metal microelectrodes with carbon nanotubes and carbon nanotube/conductive polymer composite materials. We will measure effects of these coatings on electrode capacitance and impedance, and examine the coating morphology and composition using scanning electron microscopy and energy-dispersive X-ray analysis. We present data that demonstrates that carbon nanotube coated electrodes dramatically increase the ability to electrically stimulate and record from neural tissue. This grant will allow perfecting the ability to precisely coat commercially available microelectrodes with nanoscale materials and quantify the electrochemical performance increases imparted by the coatings. The ability to reliably and reproducibly apply nanotube coatings to microelectrodes means Plexon can expand its current business model to include a consumables product line. The electrodes we will coat are already widely used in the research and clinical communities, permitting customers to improve their recording and stimulating capabilities without requiring the purchase of expensive equipment or modifying their techniques. PUBLIC HEALTH RELEVANCE Electrical stimulation of nerve cells through implanted electrodes is widely employed in neural prostheses for supplementing impaired hearing and vision, and has become central to a number of clinical therapies to treat conditions such as Parkinson's disease, dystonia, and chronic pain. The performance of current electrodes degrades over time; thus the neural prostheses using them have limited lifetimes. We have shown that modifying active sites of the electrodes with carbon nanotubes yields dramatic improvements in the ability to communicate with nerve cells, potentially yielding large increases in the useful life of neural prosthetic devices, with concomitant improvements in the quality of life for the prosthetic patient.

描述（由申请人提供）：Plexon Inc将用碳纳米管和碳纳米管/导电聚合物复合材料涂覆金属微电极的活性部位。我们将测量这些涂层对电极电容和阻抗的影响，并使用扫描电子显微镜和能量色散X射线分析来检查涂层的形态和组成。我们目前的数据表明，碳纳米管涂层电极显着增加的能力，电刺激和记录从神经组织。该补助金将允许完善用纳米级材料精确涂覆市售微电极的能力，并量化涂层赋予的电化学性能增加。Plexon能够可靠且可重复地将纳米管涂层应用于微电极，这意味着Plexon可以扩展其当前的业务模式，将耗材产品线包括在内。我们将涂覆的电极已经广泛用于研究和临床领域，允许客户在不需要购买昂贵设备或修改技术的情况下提高其记录和刺激能力。公共卫生相关性通过植入电极对神经细胞进行电刺激被广泛用于神经假体中，以补充受损的听力和视力，并且已经成为治疗诸如帕金森病、肌张力障碍和慢性疼痛等病症的许多临床疗法的核心。电流电极的性能随着时间的推移而退化;因此使用它们的神经假体具有有限的寿命。我们已经证明，用碳纳米管修饰电极的活性位点可以显著改善与神经细胞的通信能力，从而可能大幅增加神经假体装置的使用寿命，同时改善假体患者的生活质量。