NEURAL BASIS FOR THE PRODUCTION AND PERCEPTION OF PROSODY

韵律产生和感知的神经基础

• 批准号: 7921465
• 负责人: Lisa Sarah Aziz-Zadeh
• 金额: $ 8.02万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7921465
• 关键词: Affect; Affective; Area; Auditory; Autistic Disorder; Brain; Brain Diseases; Brain Injuries; Brain Mapping; Communication; Craniocerebral Trauma; Data; Emotional; Emotions; Empathy; Functional Magnetic Resonance Imaging; Future; Goals; Human; Individual; Individual Differences; Inferior frontal gyrus; Investigation; Language; Left; Linguistics; Literature; Maps; Measures; Mental disorders; Motor; Neurobiology; Neurologic; Pain; Perception; Personality inventories; Process; Production; Reporting; Request for Applications; Research; Sensory; Simulate; Social Interaction; Speech; Stroke; System; base; behavior measurement; improved; mirror neuron system; nervous system disorder; neuromechanism; phrases; programs; psychopathic personality; public health relevance; relating to nervous system; social; social communication; somatosensory; sound; syntax

DESCRIPTION (provided by applicant): Prosody, the melody and intonation of speech, is an extremely important and usually undervalued component of human communication. A significant component of human social interactions depends on prosody. The aim of the present project is to explore the application of recent approaches and concepts in human brain mapping to the study of perception and production of prosody. The initial goal of the research is to determine the degree to which perception and production of prosody rely on shared neural systems. This will be determined by an fMRI study of regions of overlap in the inferior frontal gyrus (IFG) during the perception and production of a meaningless phrase in different prosodic intonations. A second goal is to determine individual differences in this shared circuitry for perception and production. Here, we ask: Why are some people better than others at picking up subtle intonations in speech? Are such people more empathetic to the emotions of other people? Are they better at simulating another's prosodic input onto their own motor representations? To explore these questions, subjects will complete behavioral measures in prosody production, perception, and/or empathy. Scores on these measures will be correlated with brain activity in the region of the IFG previously identified as active in that individual for both prosody perception and production. Elucidating the neural basis of prosody will make an important contribution to the neurobiology of non-verbal communication, and by extension, of social communication. Furthermore, this research will improve the understanding of the communication deficits which result from brain injury, as well as the understanding of core deficits of socially isolating neurological and psychiatric disorders (such as stroke, traumatic head injury, autism). PUBLIC HEALTH RELEVANCE: One of the primary mechanisms of communication and social interaction is the exchange of prosodic information. Understanding the neural basis of prosody will make an important contribution to elucidating the neurobiology of non-verbal communication, and by extension, of social communication. Also, this is important for better understanding core deficits of socially isolating psychiatric and neurological disorders, such as autism and traumatic head injury.

描述（由申请人提供）：韵律，语音的旋律和语调，是人类交流的一个非常重要的组成部分，通常被低估。人类社会互动的一个重要组成部分取决于韵律。本项目的目的是探索应用最新的方法和概念，在人类大脑映射的研究知觉和生产的韵律。研究的最初目标是确定韵律的感知和产生依赖于共享神经系统的程度。这将通过对不同韵律语调中无意义短语的感知和产生过程中额下回（IFG）重叠区域的fMRI研究来确定。第二个目标是确定感知和生产共享回路中的个体差异。在这里，我们要问：为什么有些人比其他人更善于捕捉言语中微妙的语调？这样的人是否更容易理解他人的情绪？他们是否更善于将他人的韵律输入模拟到自己的运动表征中？为了探索这些问题，受试者将完成韵律产生，感知和/或同理心的行为测量。这些测量的分数将与IFG区域中的大脑活动相关，IFG区域先前被识别为在该个体中对于韵律感知和产生都是活跃的。阐明韵律的神经基础将对非言语交际的神经生物学做出重要贡献，并延伸到社会交际。此外，这项研究将提高对脑损伤导致的沟通缺陷的理解，以及对社会隔离神经和精神疾病（如中风，创伤性头部损伤，自闭症）的核心缺陷的理解。 公共卫生相关性：交流和社会互动的主要机制之一是韵律信息的交换。了解韵律的神经基础将为阐明非语言交流的神经生物学以及社交交流的神经生物学做出重要贡献。此外，这对于更好地理解社会孤立精神和神经系统疾病（如自闭症和创伤性头部损伤）的核心缺陷也很重要。