Integrative computational approach to the role Of myocardial structure in myocardial function and dysfunction

心肌结构在心肌功能和功能障碍中的作用的综合计算方法

• 批准号: G0701785/1
• 负责人: Stephen Gilbert
• 金额: $ 46.85万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701785%2F1
• 关键词: Integrative; computational; approach; role; myocardial

We are trying to discover how the complex three-dimensional structure of the heart muscle effects the conduction of electrical excitation that drives each heart beat.It has been shown, by us and others, that the muscle cells of the heart are organised into an intricate highly complex structural network, which is paradoxically both highly regular and highly variable. Structure is known to influence the spread of electricity in both health and disease, but the details of this are not known. Structural changes through the heart wall together with differences in electrical properties are thought to play a role in the success or failure of defibrillation.Investigating cardiac electrical conduction is a challenge in living people as it would require imaging the structure and excitation of the beating heart.We will investigate this question using the rabbit as an animal model. We will probe the microscopic structure of the normal and diseased heart using medical imaging methods and we will record the movement of excitation through the heart using dyes which change colour depending on voltage. This information will be analysed using a sophisticated computer model. We will address the important question: how is the heart rhythm affected by heart structure?

我们正试图发现心肌复杂的三维结构是如何影响驱动每一次心跳的电兴奋传导的。我们和其他人已经证明，心脏的肌肉细胞被组织成一个复杂的高度复杂的结构网络，这是一个矛盾的高度规则和高度可变的结构网络。众所周知，结构会影响电在健康和疾病中的传播，但这方面的细节尚不清楚。心脏壁的结构变化和电学特性的差异被认为对除颤的成败起到了作用。研究心脏传导是一个挑战，因为它需要对心脏跳动的结构和兴奋进行成像。我们将使用兔子作为动物模型来研究这个问题。我们将使用医学成像方法探索正常和疾病心脏的微观结构，并使用根据电压改变颜色的染料来记录心脏中兴奋的运动。这些信息将使用复杂的计算机模型进行分析。我们将解决一个重要的问题：心脏结构是如何影响心率的？