Association of Type 2 Diabetes with Liver and Muscle Adiposity in Black Men

黑人男性 2 型糖尿病与肝脏和肌肉肥胖的关系

• 批准号: 8165517
• 负责人: IVA MILJKOVIC
• 金额: $ 7.58万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-05 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8165517
• 关键词: Abdomen; Abdominal Muscles; Address; Admixture; Affect; African; African American; Aging; Alcohol consumption; Award; Body fat; Bone Density; Central obesity; Choristoma; Collaborations; Confounding Factors (Epidemiology); Data; Development; Diabetes Mellitus; Epidemiology; Fatty acid glycerol esters; Foundations; Future; Goals; Health; Hepatic; High Prevalence; Image; Individual; Infiltration; K-Series Research Career Programs; Leg; Liver; Longitudinal Studies; Low Prevalence; Measures; Muscle; Non obese; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pharmacotherapy; Pilot Projects; Population; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Risk Factors; Role; Scanning; Skeletal Muscle; Smoking; Testing; Time; Tobago; Training; Universities; Visceral; Visit; West Indies; X-Ray Computed Tomography; aged; career; cohort; cost; diabetes risk; diabetic; epidemiology study; experience; forest; high risk; high risk men; insight; male; men; novel; programs; subcutaneous

DESCRIPTION (provided by applicant): Obesity and type 2 diabetes (T2D) are escalating at alarming rates and disproportionately affect black individuals. High T2D rates observed among blacks cannot be explained by obesity or other established risk factors. Emerging evidence indicates that accumulation of fat in non-adipose tissues (ectopic fat), such as in skeletal muscle and liver, contributes to the development of T2D, independent of obesity. However, it is still unclear if and how these fat depots influence T2D, particularly among high-risk black populations. There remains a need to better understand the role of ectopic fat in T2D especially in black populations. Through the Career Development Award (K01-DK083029) the applicant is currently investigating the epidemiology of skeletal muscle fat infiltration in a well-characterized cohort of black men from the Tobago Health Study. This cohort offers a unique opportunity to study a black population with very little non-African admixture, low levels of total adiposity, low prevalence of potential confounding variables, but with a high prevalence of T2D, especially among non-obese men. Building on this existing study of skeletal muscle fat infiltration, we are proposing a pilot study to add critical measures of abdominal visceral, subcutaneous, muscle, and hepatic fat accumulation by computed tomography (CT) in 300 black men (150 with and 150 without T2D) from the Tobago Health Study, aged 40-80 years. These newly collected data will enable us to test the hypotheses that compared to black men without T2D, black men with T2D have greater fat infiltration 1) in skeletal muscle, and, 2) in liver, independent of visceral, subcutaneous and total body fat. The proposed pilot study will provide important new insight on visceral, muscular, and hepatic fat infiltration and their individual and collective relationship with T2D in a black population at high risk of diabetes. It will also generate essential preliminary data to support a larger scale proposal of ectopic fat infiltration in skeletal muscle and liver. It will also lay the foundation for a future longitudinal study of changes in ectopic fat depots with aging and the relationships of these changes to T2D risk. Finally, the proposed research will be an important step in the applicant's long-term goal to characterize the epidemiology of ectopic fat and to investigate its role in T2D in black populations. PUBLIC HEALTH RELEVANCE: Obesity and type 2 diabetes (T2D) are escalating at alarming rates and disproportionately affect black individuals. High T2D rates observed among blacks cannot be explained by obesity or other established risk factors. Emerging evidence indicates that accumulation of fat in non-adipose tissues (ectopic fat) contributes to the development of T2D, independent of obesity. However, it is still unclear if and how these fat depots influence T2D, particularly among high-risk black populations. Building on the existing study of skeletal muscle fat infiltration in black men at high risk of T2D, we are proposing a pilot study to extend our current measures of adiposity. We will obtain critical measures of abdominal visceral, subcutaneous, muscle, and hepatic fat accumulation by computed tomography (CT), and test for an association with T2D. The proposed pilot study will provide important new insight on visceral, muscular, and hepatic fat infiltration and their individual and collective relationship with T2D in a black population, and will further facilitate the applicant's transition to an independent investigator.

描述（由申请人提供）：肥胖和2型糖尿病（T2 D）正在以惊人的速度升级，并不成比例地影响黑人个体。在黑人中观察到的高T2 D率不能用肥胖或其他已知的风险因素来解释。新出现的证据表明，脂肪在非脂肪组织（异位脂肪），如骨骼肌和肝脏中的积累，有助于T2 D的发展，与肥胖无关。然而，目前尚不清楚这些脂肪库是否以及如何影响T2 D，特别是在高风险黑人人群中。仍然需要更好地了解异位脂肪在T2 D中的作用，特别是在黑人人群中。通过职业发展奖（K 01-DK 083029），申请人目前正在调查托巴哥健康研究中一个特征良好的黑人男性队列中骨骼肌脂肪浸润的流行病学。该队列提供了一个独特的机会来研究黑人人群，他们的非非洲混血儿很少，总肥胖水平低，潜在混杂变量的患病率低，但T2 D的患病率高，特别是在非肥胖男性中。在现有的骨骼肌脂肪浸润研究的基础上，我们提出了一项试点研究，在托巴哥健康研究的300名黑人男性（150名患有T2 D，150名没有T2 D）中，通过计算机断层扫描（CT）增加腹部内脏、皮下、肌肉和肝脏脂肪蓄积的关键指标，年龄为40-80岁。这些新收集的数据将使我们能够检验以下假设：与没有T2 D的黑人男性相比，患有T2 D的黑人男性1）骨骼肌中的脂肪浸润更大，2）肝脏中的脂肪浸润更大，与内脏、皮下和全身脂肪无关。拟议的试点研究将提供重要的新见解内脏，肌肉和肝脏脂肪浸润及其与T2 D的个体和集体关系在黑人人群中糖尿病的高风险。它还将产生必要的初步数据，以支持骨骼肌和肝脏异位脂肪浸润的更大规模的建议。这也将为未来的纵向研究奠定基础，研究异位脂肪库随年龄增长的变化以及这些变化与T2 D风险的关系。最后，拟议的研究将是申请人长期目标的重要一步，以表征异位脂肪的流行病学，并调查其在黑人人群中的T2 D中的作用。 公共卫生相关性：肥胖和2型糖尿病（T2 D）正在以惊人的速度升级，并不成比例地影响黑人。在黑人中观察到的高T2 D率不能用肥胖或其他已知的风险因素来解释。新出现的证据表明，脂肪在非脂肪组织（异位脂肪）中的积累有助于T2 D的发展，与肥胖无关。然而，目前尚不清楚这些脂肪库是否以及如何影响T2 D，特别是在高风险黑人人群中。在现有的研究基础上，在黑人男性T2 D的高风险骨骼肌脂肪浸润，我们提出了一个试点研究，以扩大我们目前的肥胖的措施。我们将通过计算机断层扫描（CT）获得腹部内脏、皮下、肌肉和肝脏脂肪蓄积的关键指标，并检测与T2 D的相关性。拟议的初步研究将提供关于黑人人群中内脏、肌肉和肝脏脂肪浸润及其与T2 D的个体和集体关系的重要新见解，并将进一步促进申请人向独立研究者的过渡。