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The Study of Muscle and Physical Performance in African Caribbeans.

非洲加勒比海地区肌肉和身体表现的研究。

基本信息

批准号：
10598636
负责人：
IVA MILJKOVIC
金额：
$ 63.5万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2026-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10598636
关键词：
Acceleration Address Admixture Adult Aerobic Africa African African American population African Caribbean African ancestry Age Aging Biological Assay Black race Body Composition Body fat Body measure procedure Caribbean region Caucasians Clinical Connective Tissue Creatine Data Diabetes Mellitus Dual-Energy X-Ray Absorptiometry Elderly European European ancestry Exercise Exercise Tolerance Family Fatty acid glycerol esters Foundations Funding Future Genetic Geographic Locations Habits Health Health Care Costs Healthcare Hypertension Immigrant Impairment Individual Infiltration Institutionalization Insulin Resistance Investigation Island Life Style Longevity Measures Medical History Metabolism Methods Muscle Muscle Weakness Muscular Atrophy Obesity Out-Migrations Outcome Participant Pathway interactions Patient Self-Report Pattern Pharmaceutical Preparations Phenotype Physical Function Physical Performance Population Population Research Predisposition Premature Mortality Prevention Public Health Quality of life Research Risk Factors Skeletal Muscle Testing Thinness Time Tobago United States National Institutes of Health Walking Water Woman age related age-related muscle loss aged cohort design disability epidemiology study high risk population improved interest men mortality muscle form muscle strength novel oxidation prevent protective factors recruit reduced muscle mass reduced muscle strength retention rate standard measure

项目摘要

PROJECT SUMMARY/ABSTRACT Declines in physical function with aging are an enormous clinical and public health problem that lead to increased disability, institutionalization, health care costs, lower quality of life and premature mortality. The burden of physical limitations and disability is higher in African compared with Caucasian individuals. Compounding the issue, older African Ancestry populations represent a rapidly growing segment of the population, especially outside the USA. For example, the number of individuals aged ≥60 in the Caribbean is expected to increase from 59 to 196 million by 2050. Black immigrants from the Caribbean differ from U.S. born African Americans and Black immigrants from Africa in rates of high blood pressure, diabetes, and obesity. These differences may be due in part to the greater Caucasian European Admixture (~25%) in African Americans compared with African Caribbeans (~6%). Yet, despite the clear scientific premise and need – there are no studies specifically designed to thoroughly examine physical function in African Caribbeans. Over the past 20 years, we have been studying a large cohort of African Caribbean men and women from Tobago in whom we have extensive measures of lifestyle habits, family and medical history, body composition, and biospecimens. We found that African Caribbeans have more lean mass (estimated muscle mass), but weaker muscle strength and higher levels of muscle fat than US adults. We have also discovered that changes in fat mass, but not lean mass, are important for future walking ability. However, many important gaps remain, and it is critical to expand measures of physical performance in this cohort. Therefore, we are proposing to address these gaps in the field by directly measuring skeletal muscle mass (d3 creatine dilution [D3Cr]) and performing deeper phenotyping of physical performance measures at each level in the disablement pathway to gain a comprehensive understanding of physical performance in this unique cohort of 1700 African Caribbeans. Aim 1 will use a wealth of existing data to test the hypothesis that both risk and protective factors more pronounced in African Caribbeans – specifically higher genetic African admixture, diabetes, and muscle fat infiltration - will be associated with changes in physical function with aging. Aims 2 and 3 will focus on new measures of body composition and physical performance that we are proposing to collect to test the hypotheses that: 1) lower muscle mass and greater muscle fat infiltration will be related to greater fatigability and worse physical performance, and 2) that poorer fat oxidation during walking will be associated with greater total fat and muscle fat, as well as greater fatigability and worse physical performance. Successful completion of these aims will provide the first direct assessment of skeletal muscle mass and comprehensive investigation of physical performance in African Caribbeans, a vastly under- studied, but rapidly growing population and lay the foundation for future investigations. These data can be harnessed in future efforts to improve, prevention, and treatment of age-related declines in physical performance.

项目总结/文摘