Association of Type 2 Diabetes with Liver and Muscle Adiposity in Black Men

黑人男性 2 型糖尿病与肝脏和肌肉肥胖的关系

• 批准号: 8328607
• 负责人: IVA MILJKOVIC
• 金额: $ 8.76万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-05 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8328607
• 关键词: Abdomen; Abdominal Muscles; Address; Admixture; Affect; African; African American; Aging; Alcohol consumption; Award; Body fat; Bone Density; Central obesity; Choristoma; Collaborations; Confounding Factors (Epidemiology); Data; Development; Diabetes Mellitus; Epidemiology; Fatty acid glycerol esters; Foundations; Future; Goals; Health; Hepatic; High Prevalence; Image; Individual; Infiltration; K-Series Research Career Programs; Leg; Liver; Longitudinal Studies; Low Prevalence; Measures; Muscle; Non obese; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pharmacotherapy; Pilot Projects; Population; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Risk Factors; Role; Scanning; Skeletal Muscle; Smoking; Testing; Time; Tobago; Training; Universities; Visceral; Visit; West Indies; X-Ray Computed Tomography; aged; career; cohort; cost; diabetes risk; diabetic; epidemiology study; experience; forest; high risk; high risk men; insight; male; men; novel; programs; subcutaneous

DESCRIPTION (provided by applicant): Obesity and type 2 diabetes (T2D) are escalating at alarming rates and disproportionately affect black individuals. High T2D rates observed among blacks cannot be explained by obesity or other established risk factors. Emerging evidence indicates that accumulation of fat in non-adipose tissues (ectopic fat), such as in skeletal muscle and liver, contributes to the development of T2D, independent of obesity. However, it is still unclear if and how these fat depots influence T2D, particularly among high-risk black populations. There remains a need to better understand the role of ectopic fat in T2D especially in black populations. Through the Career Development Award (K01-DK083029) the applicant is currently investigating the epidemiology of skeletal muscle fat infiltration in a well-characterized cohort of black men from the Tobago Health Study. This cohort offers a unique opportunity to study a black population with very little non-African admixture, low levels of total adiposity, low prevalence of potential confounding variables, but with a high prevalence of T2D, especially among non-obese men. Building on this existing study of skeletal muscle fat infiltration, we are proposing a pilot study to add critical measures of abdominal visceral, subcutaneous, muscle, and hepatic fat accumulation by computed tomography (CT) in 300 black men (150 with and 150 without T2D) from the Tobago Health Study, aged 40-80 years. These newly collected data will enable us to test the hypotheses that compared to black men without T2D, black men with T2D have greater fat infiltration 1) in skeletal muscle, and, 2) in liver, independent of visceral, subcutaneous and total body fat. The proposed pilot study will provide important new insight on visceral, muscular, and hepatic fat infiltration and their individual and collective relationship with T2D in a black population at high risk of diabetes. It will also generate essential preliminary data to support a larger scale proposal of ectopic fat infiltration in skeletal muscle and liver. It will also lay the foundation for a future longitudinal study of changes in ectopic fat depots with aging and the relationships of these changes to T2D risk. Finally, the proposed research will be an important step in the applicant's long-term goal to characterize the epidemiology of ectopic fat and to investigate its role in T2D in black populations.

描述（由申请人提供）：肥胖和 2 型糖尿病 (T2D) 正在以惊人的速度升级，并且对黑人的影响尤为严重。在黑人中观察到的高 T2D 发病率不能用肥胖或其他既定危险因素来解释。新的证据表明，非脂肪组织（异位脂肪）（例如骨骼肌和肝脏）中的脂肪积累会导致 T2D 的发生，而与肥胖无关。然而，目前尚不清楚这些脂肪库是否以及如何影响 T2D，特别是在高危黑人群体中。仍然需要更好地了解异位脂肪在 T2D 中的作用，尤其是在黑人群体中。通过职业发展奖（K01-DK083029），申请人目前正在多巴哥健康研究中调查一组特征明确的黑人男性中骨骼肌脂肪浸润的流行病学。该队列提供了一个独特的机会来研究非非洲混血很少、总体肥胖水平较低、潜在混杂变量患病率较低、但 T2D 患病率较高的黑人群体，尤其是在非肥胖男性中。在这项现有的骨骼肌脂肪浸润研究的基础上，我们提议开展一项试点研究，通过计算机断层扫描 (CT) 对来自多巴哥健康研究的 300 名 40-80 岁黑人男性（其中 150 名患有 T2D，150 名未患有 T2D）增加腹部内脏、皮下、肌肉和肝脏脂肪积累的关键测量。这些新收集的数据将使我们能够检验以下假设：与未患 T2D 的黑人相比，患有 T2D 的黑人在 1) 骨骼肌和 2) 肝脏中具有更大的脂肪浸润，与内脏、皮下和全身脂肪无关。拟议的试点研究将为糖尿病高危黑人群体的内脏、肌肉和肝脏脂肪浸润及其与 T2D 的个体和集体关系提供重要的新见解。它还将生成重要的初步数据，以支持骨骼肌和肝脏异位脂肪浸润的更大规模提议。它还将为未来纵向研究异位脂肪库随衰老的变化以及这些变化与 T2D 风险的关系奠定基础。最后，拟议的研究将是申请人的长期目标的重要一步，该目标是描述异位脂肪的流行病学特征并调查其在黑人人群中 T2D 中的作用。