Gender Differences in Outcomes and Genetic Associations of Rheumatoid Arthritis

类风湿关节炎的结果和遗传关联的性别差异

• 批准号: 8060529
• 负责人: Damini Jawaheer
• 金额: $ 12.03万
• 依托单位: CHILDREN'S HOSPITAL & RES CTR AT OAKLAND
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-11 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8060529
• 关键词: Accounting; Age; Alleles; Anti-citrullinated peptide antibody; Applications Grants; Autoantibodies; Award; Candidate Disease Gene; Clinic; Clinical; Communities; Complement; Complex; Consultations; Data; Data Analyses; Data Set; Development Plans; Disease; Environment; Epidemiologic Methods; Epidemiology; Family; Female; Finland; Funding; Gender; Genes; Genetic; Goals; HLA-DRB1; Investigation; Journals; K-Series Research Career Programs; Knowledge; Manuscripts; Mentored Research Scientist Development Award; Mentorship; Methods; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Onset of illness; Outcome; Patient Representative; Patients; Peer Review; Phenotype; Population; Preparation; Prognostic Marker; Rank-Sum Tests; Regression Analysis; Research; Research Design; Research Personnel; Resources; Rheumatism; Rheumatoid Arthritis; Rheumatology; Risk; Risk Factors; Sampling; Selection Criteria; Severity of illness; Sex Bias; Sex Characteristics; Solid; Statistical Models; Testing; Training; Treatment outcome; base; career development; cohort; design; epidemiology study; experience; genetic association; genetic epidemiology; genetic risk factor; illness length; male; meetings; non-genetic; outcome forecast; population based; prospective; response; rheumatologist; sex; skills; trend

DESCRIPTION (provided by applicant): This proposal is for 5 years of funding for a NIAMS Career Development Award, through the mechanism of the Mentored Research Scientist Development Award (K01) program. The goal of the training award is to develop the candidate's knowledge and skills in epidemiologic methods, data analysis and interpretation, as well as to provide her with a solid understanding of clinical rheumatology in terms of disease manifestations, treatment and treatment outcomes, to complement the expertise that she has already gathered in the genetics of rheumatoid arthritis (RA), leading to her transition to being able to independently conduct genetic epidemiology studies. The career development plan will develop the candidate's skills in 1) epidemiology methods and applications to complex disease research, 2) clinical rheumatology, and 3) application of epidemiology methods to genetic data within the context of gene association studies. Methods of career development include 1) the proposed study, 2) the mentorship of Drs. Nelson Freimer, Lindsey Criswell and Jorn Olsen, 3) consultation with experts in clinical rheumatology, and observation at rheumatology clinics, 4) formal coursework in epidemiology, leading to a Masters in Epidemiology, 5) attendance at scientific meetings, 6) data preparation for submission of manuscripts to peer-reviewed journals, and preparation of R01 grant application using preliminary data generated from this career development award. The main objective of the research plan is to examine gender differences in disease features, responses to treatment, and associations with candidate gene markers among RA patients, using epidemiological methods. These aims will test the hypothesis that male RA patients, in particular those with younger age at onset, have a higher load of genetic and non-genetic risk factors for the disease, and hence have more severe disease manifestations and possibly different responses to treatment. A better understanding of the sex differences in RA might provide clues about underlying disease mechanisms and could also have an important impact on RA prognosis and therapy. With the proposed mentorship, outstanding resources, research environment and the candidate's prior training, a K01 award will facilitate the candidate's transition to becoming an independent researcher in the field of rheumatic disease genetics.

说明（由申请人提供）：本提案旨在通过指导研究科学家发展奖 (K01) 计划的机制，为 NIAMS 职业发展奖提供为期 5 年的资助。培训奖的目标是培养候选人在流行病学方法、数据分析和解释方面的知识和技能，并让她对临床风湿病的疾病表现、治疗和治疗结果有一个扎实的了解，以补充她在类风湿性关节炎（RA）遗传学方面已经积累的专业知识，使她能够独立进行遗传流行病学研究。职业发展计划将培养候选人以下方面的技能：1）流行病学方法及其在复杂疾病研究中的应用，2）临床风湿病学，3）流行病学方法在基因关联研究背景下对遗传数据的应用。职业发展的方法包括 1) 拟议的研究，2) 博士的指导。 Nelson Freimer、Lindsey Criswell 和 Jorn Olsen，3) 咨询临床风湿病学专家，并在风湿病诊所观察，4) 流行病学正式课程，获得流行病学硕士学位，5) 参加科学会议，6) 准备向同行评审期刊提交稿件的数据，并使用 R01 拨款申请准备 该职业发展奖产生的初步数据。该研究计划的主要目标是利用流行病学方法检查 RA 患者疾病特征、治疗反应以及与候选基因标记的关联方面的性别差异。这些目标将检验以下假设：男性 RA 患者，特别是发病年龄较小的患者，具有较高的遗传和非遗传风险因素，因此有更严重的疾病表现，并且对治疗的反应可能不同。更好地了解 RA 的性别差异可能会提供有关潜在疾病机制的线索，也可能对 RA 的预后和治疗产生重要影响。凭借拟议的指导、优秀的资源、研究环境和候选人之前的培训，K01 奖将有助于候选人过渡成为风湿病遗传学领域的独立研究员。

项目成果

Gender, body mass index and rheumatoid arthritis disease activity: results from the QUEST-RA Study.

性别、体重指数和类风湿性关节炎疾病活动性：QUEST-RA 研究的结果。

• 发表时间: 2010
• 期刊: Clinical and experimental rheumatology
• 影响因子: 3.7
• 作者: Jawaheer,D;Olsen,J;Lahiff,M;Forsberg,S;Lähteenmäki,J;daSilveira,IG;Rocha,FA;MagalhãesLaurindo,IM;HenriquedaMota,LM;Drosos,AA;Murphy,E;Sheehy,C;Quirke,E;Cutolo,M;Rexhepi,S;Dadoniene,J;Verstappen,SMM;Sokka,T;QU
• 通讯作者: QU