Gender Differences in Outcomes and Genetic Associations of Rheumatoid Arthritis

类风湿关节炎的结果和遗传关联的性别差异

• 批准号: 8060529
• 负责人: Damini Jawaheer
• 金额: $ 12.03万
• 依托单位: CHILDREN'S HOSPITAL & RES CTR AT OAKLAND
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-11 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8060529
• 关键词: Accounting; Age; Alleles; Anti-citrullinated peptide antibody; Applications Grants; Autoantibodies; Award; Candidate Disease Gene; Clinic; Clinical; Communities; Complement; Complex; Consultations; Data; Data Analyses; Data Set; Development Plans; Disease; Environment; Epidemiologic Methods; Epidemiology; Family; Female; Finland; Funding; Gender; Genes; Genetic; Goals; HLA-DRB1; Investigation; Journals; K-Series Research Career Programs; Knowledge; Manuscripts; Mentored Research Scientist Development Award; Mentorship; Methods; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Onset of illness; Outcome; Patient Representative; Patients; Peer Review; Phenotype; Population; Preparation; Prognostic Marker; Rank-Sum Tests; Regression Analysis; Research; Research Design; Research Personnel; Resources; Rheumatism; Rheumatoid Arthritis; Rheumatology; Risk; Risk Factors; Sampling; Selection Criteria; Severity of illness; Sex Bias; Sex Characteristics; Solid; Statistical Models; Testing; Training; Treatment outcome; base; career development; cohort; design; epidemiology study; experience; genetic association; genetic epidemiology; genetic risk factor; illness length; male; meetings; non-genetic; outcome forecast; population based; prospective; response; rheumatologist; sex; skills; trend

DESCRIPTION (provided by applicant): This proposal is for 5 years of funding for a NIAMS Career Development Award, through the mechanism of the Mentored Research Scientist Development Award (K01) program. The goal of the training award is to develop the candidate's knowledge and skills in epidemiologic methods, data analysis and interpretation, as well as to provide her with a solid understanding of clinical rheumatology in terms of disease manifestations, treatment and treatment outcomes, to complement the expertise that she has already gathered in the genetics of rheumatoid arthritis (RA), leading to her transition to being able to independently conduct genetic epidemiology studies. The career development plan will develop the candidate's skills in 1) epidemiology methods and applications to complex disease research, 2) clinical rheumatology, and 3) application of epidemiology methods to genetic data within the context of gene association studies. Methods of career development include 1) the proposed study, 2) the mentorship of Drs. Nelson Freimer, Lindsey Criswell and Jorn Olsen, 3) consultation with experts in clinical rheumatology, and observation at rheumatology clinics, 4) formal coursework in epidemiology, leading to a Masters in Epidemiology, 5) attendance at scientific meetings, 6) data preparation for submission of manuscripts to peer-reviewed journals, and preparation of R01 grant application using preliminary data generated from this career development award. The main objective of the research plan is to examine gender differences in disease features, responses to treatment, and associations with candidate gene markers among RA patients, using epidemiological methods. These aims will test the hypothesis that male RA patients, in particular those with younger age at onset, have a higher load of genetic and non-genetic risk factors for the disease, and hence have more severe disease manifestations and possibly different responses to treatment. A better understanding of the sex differences in RA might provide clues about underlying disease mechanisms and could also have an important impact on RA prognosis and therapy. With the proposed mentorship, outstanding resources, research environment and the candidate's prior training, a K01 award will facilitate the candidate's transition to becoming an independent researcher in the field of rheumatic disease genetics.

描述（由申请人提供）：该提案是通过指导研究科学家发展奖（K01）计划的机制为NIAMS职业发展奖的5年资金。 The goal of the training award is to develop the candidate's knowledge and skills in epidemiologic methods, data analysis and interpretation, as well as to provide her with a solid understanding of clinical rheumatology in terms of disease manifestations, treatment and treatment outcomes, to complement the expertise that she has already gathered in the genetics of rheumatoid arthritis (RA), leading to her transition to being able to independently conduct genetic epidemiology studies.职业发展计划将在1）复杂疾病研究中的流行病学方法和应用中发展候选人的技能，2）临床风湿病学和3）在基因关联研究背景下，将流行病学方法应用于遗传数据。职业发展方法包括1）拟议的研究，2）DRS的指导。 Nelson Freimer，Lindsey Criswell和Jorn Olsen，3）与临床风湿病学专家进行磋商，在风湿病学诊所进行观察，4）4）正式的流行病学课程工作，导致流行病学的硕士，5）5）在科学会议上进行竞争，6）供科学会议，6）数据准备，以供数据准备及其培训，并准备好竞争及PEERECRICTS TOERE-RENNE-REDER-0该职业发展奖产生的初步数据。研究计划的主要目的是使用流行病学方法检查RA患者中疾病特征，对治疗的反应以及与候选基因标记的性别差异。这些目标将检验以下假设：雄性RA患者，尤其是那些年龄较小的患者对疾病的遗传和非遗传危险因素较高，因此具有更严重的疾病表现，并且可能对治疗的反应不同。更好地了解RA的性别差异可能会提供有关潜在疾病机制的线索，并且还可能对RA预后和治疗产生重要影响。借助拟议的指导，杰出的资源，研究环境和候选人的先前培训，K01奖将有助于候选人过渡到成为风湿病遗传学领域的独立研究人员。

项目成果

Gender, body mass index and rheumatoid arthritis disease activity: results from the QUEST-RA Study.

性别、体重指数和类风湿性关节炎疾病活动性：QUEST-RA 研究的结果。

• 发表时间: 2010
• 期刊: Clinical and experimental rheumatology
• 影响因子: 3.7
• 作者: Jawaheer,D;Olsen,J;Lahiff,M;Forsberg,S;Lähteenmäki,J;daSilveira,IG;Rocha,FA;MagalhãesLaurindo,IM;HenriquedaMota,LM;Drosos,AA;Murphy,E;Sheehy,C;Quirke,E;Cutolo,M;Rexhepi,S;Dadoniene,J;Verstappen,SMM;Sokka,T;QU
• 通讯作者: QU