Gender Differences in Outcomes and Genetic Associations of Rheumatoid Arthritis

类风湿关节炎的结果和遗传关联的性别差异

• 批准号: 7620915
• 负责人: Damini Jawaheer
• 金额: $ 12.03万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-11 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7620915
• 关键词: Accounting; Age; Alleles; Anti-citrullinated peptide antibody; Applications Grants; Autoantibodies; Award; Candidate Disease Gene; Clinic; Clinical; Communities; Complement; Complex; Consultations; Data; Data Analyses; Data Set; Development Plans; Disease; Environment; Epidemiologic Methods; Epidemiology; Family; Female; Finland; Funding; Gender; Genes; Genetic; Genetic Load; Goals; HLA-DRB1; Investigation; Journals; K-Series Research Career Programs; Knowledge; Manuscripts; Mentored Research Scientist Development Award; Mentorship; Methods; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Onset of illness; Outcome; Patient Representative; Patients; Peer Review; Phenotype; Population; Preparation; Prognostic Marker; Rank-Sum Tests; Regression Analysis; Research; Research Design; Research Personnel; Resources; Rheumatism; Rheumatoid Arthritis; Rheumatology; Risk; Risk Factors; Sampling; Selection Criteria; Severity of illness; Sex Bias; Sex Characteristics; Solid; Statistical Models; Testing; Training; Treatment outcome; base; career development; cohort; design; epidemiology study; experience; genetic association; genetic epidemiology; genetic risk factor; illness length; male; meetings; non-genetic; outcome forecast; population based; prospective; response; rheumatologist; sex; skills; trend

DESCRIPTION (provided by applicant): This proposal is for 5 years of funding for a NIAMS Career Development Award, through the mechanism of the Mentored Research Scientist Development Award (K01) program. The goal of the training award is to develop the candidate's knowledge and skills in epidemiologic methods, data analysis and interpretation, as well as to provide her with a solid understanding of clinical rheumatology in terms of disease manifestations, treatment and treatment outcomes, to complement the expertise that she has already gathered in the genetics of rheumatoid arthritis (RA), leading to her transition to being able to independently conduct genetic epidemiology studies. The career development plan will develop the candidate's skills in 1) epidemiology methods and applications to complex disease research, 2) clinical rheumatology, and 3) application of epidemiology methods to genetic data within the context of gene association studies. Methods of career development include 1) the proposed study, 2) the mentorship of Drs. Nelson Freimer, Lindsey Criswell and Jorn Olsen, 3) consultation with experts in clinical rheumatology, and observation at rheumatology clinics, 4) formal coursework in epidemiology, leading to a Masters in Epidemiology, 5) attendance at scientific meetings, 6) data preparation for submission of manuscripts to peer-reviewed journals, and preparation of R01 grant application using preliminary data generated from this career development award. The main objective of the research plan is to examine gender differences in disease features, responses to treatment, and associations with candidate gene markers among RA patients, using epidemiological methods. These aims will test the hypothesis that male RA patients, in particular those with younger age at onset, have a higher load of genetic and non-genetic risk factors for the disease, and hence have more severe disease manifestations and possibly different responses to treatment. A better understanding of the sex differences in RA might provide clues about underlying disease mechanisms and could also have an important impact on RA prognosis and therapy. With the proposed mentorship, outstanding resources, research environment and the candidate's prior training, a K01 award will facilitate the candidate's transition to becoming an independent researcher in the field of rheumatic disease genetics.

描述(由申请者提供)：这份提案是为NIAMS职业发展奖提供5年的资金，通过导师研究科学家发展奖(K01)计划的机制。培训奖项的目的是发展候选人在流行病学方法、数据分析和解释方面的知识和技能，并使她在疾病表现、治疗和治疗结果方面对临床风湿学有扎实的了解，以补充她在类风湿性关节炎(RA)遗传学方面已经积累的专业知识，使她能够过渡到能够独立进行遗传流行病学研究。职业发展计划将培养候选人在1)流行病学方法和在复杂疾病研究中的应用，2)临床风湿学，以及3)在基因关联研究背景下将流行病学方法应用于遗传数据方面的技能。职业发展的方法包括1)拟议的研究，2)Nelson Fremer、Lindsey Criswell和Jorn Olsen博士的指导，3)咨询临床风湿学专家，并在风湿病诊所观察，4)流行病学的正式课程，导致获得流行病学硕士学位，5)参加科学会议，6)为向同行评议的期刊提交手稿做数据准备，以及使用从该职业发展奖产生的初步数据准备R01拨款申请。该研究计划的主要目的是用流行病学方法检查类风湿性关节炎患者在疾病特征、治疗反应以及与候选基因标记物的相关性方面的性别差异。这些目标将检验一种假设，即男性RA患者，特别是那些发病年龄较小的患者，具有较高的致病遗传和非遗传风险因素负载，因此具有更严重的疾病表现和可能不同的治疗反应。更好地了解类风湿关节炎的性别差异可能会为潜在的疾病机制提供线索，也可能对类风湿关节炎的预后和治疗产生重要影响。凭借建议的导师、出色的资源、研究环境和候选人之前的培训，K01奖将促进候选人过渡到风湿病遗传学领域的独立研究人员。