Molecular Analyses and Interventions for Biodefense and Emerging Pathogens

描述（由申请人提供）：我们国家检测、预防和打击生物恐怖主义和新出现的传染病的能力依赖于通过对致病微生物和人类免疫系统对它们的反应进行生物医学研究而产生的技术。国家过敏和传染病研究所（NIAID）建立了RCE网络，即生物防御和新发传染病卓越研究中心，以了解微生物病原体引起人类疾病的分子机制。获得这方面的知识有助于开发旨在预防、诊断和治疗由生物恐怖主义制剂或新出现的病原体（NIAID A-C类制剂）引起的疾病的产品。在此，我们提出了五大湖（五区）竞争性更新应用RCE，简称GLRCE。GLRCE是一个由伊利诺斯州、印第安纳州、密歇根州、明尼苏达州、俄亥俄州和威斯康星州的研究机构组成的联盟。GLRCE由芝加哥大学的行政核心组织，包括该地区所有主要的研究机构，包括阿贡国家实验室、巴特尔纪念研究所、伊利诺伊州立大学、印第安纳大学、洛约拉大学、梅奥诊所、威斯康星医学院、密歇根州立大学、圣母大学、西北大学、俄亥俄州立大学、普渡大学、芝加哥大学、辛辛那提大学、伊利诺伊大学、密歇根大学，明尼苏达大学和威斯康星大学。除了研究生物防御产品外，GLRCE还提供专业知识、教育和实验室基础设施网络，在生物防御和其他传染病紧急情况下为国家提供服务。GLRCE提出了一项公共卫生官员的教育计划，以及博士后和教师水平的科学卓越培训计划。GLRCE的研究和培训由一个机制管理，该机制包括对科学卓越和转化目标的持续审查、机构间咨询委员会和外部科学咨询机构。

DESCRIPTION (provided by applicant): Our nation's ability to detect, prevent and counter bioterrorism and emerging infectious diseases depends on technologies that are generated through biomedical research on disease-causing microbes and the human immune system's response to them. The National Institute of Allergy and Infectious Diseases (NIAID) established the RCE Network, i.e. the Research Centers of Excellence for Biodefense and Emerging Infectious Diseases, to gain appreciation of the molecular mechanisms whereby microbial pathogens cause human disease. Acquisition of this knowledge enables the development of products designed to prevent, diagnose, and treat diseases caused by agents of bioterrorism or newly emerging pathogens (NIAID Category A-C agents). We present here the Competitive Renewal Application of the Great Lakes (Region V) RCE, abbreviated GLRCE. The GLRCE\s a consortium of research institutions in Illinois, Indiana, Michigan, Minnesota, Ohio and Wisconsin. Organized by its Administrative Core at the University of Chicago, GLRCE includes all premier research institutions in this region, which are Argonne National Laboratory, Battelle Memorial Institute, Illinois State University, Indiana University, Loyola University, Mayo Clinic, Medical College of Wisconsin, Michigan State University, Notre Dame University, Northwestern University, Ohio State University, Purdue University, University of Chicago, University of Cincinnati, University of Illinois, University of Michigan, University of Minnesota, and the University of Wisconsin. In addition to research on biodefense products, the GLRCE provides a network of expertise, education and laboratory infrastructure that serves the nation during biodefense and other infectious disease emergencies. The GLRCE proposes an educational program for public health officials as well as training programs for scientific excellence at the post-doctoral and faculty level. Research and training at the GLRCE is governed by a mechanism involving ongoing review of scientific excellence and translational goals, inter-institutional advisory boards and external scientific advisory bodies. RELEVANCE: The National Institute of Allergy and Infectious Diseases (NIAID) established the RCE Network, to gain appreciation of the molecular mechanisms whereby microbial pathogens cause human disease. Acquisition of this knowledge enables the development of products designed to prevent, diagnose, and treat diseases caused by agents of bioterrorism or newly emerging pathogens (NIAID Category A-C agents). STRATEGIC MANAGEMENT PLAN/ADMINISTRATIVE CORE: Strategic Plan and Management (SMP Leader, O. Schneewind) STRATEGIC MANAGEMENT PLAN DESCRIPTION: The Administrative Core of the Great Lakes Regional Center of Excellence (GLRCE) will be led by its Director, Dr. Olaf Schneewind, Co-Director, Dr Bernard Roizman and Associate Director Navneet Bhasin, PhD. The core is designed to assure financial and administrative integrity of the GLRCE and all of its 27 affiliated institutions. The purpose of the core is to maintain scientific objective and bias-free direction and coordination of the projects; enable the RCE management to identify opportunities and to attract intellectual and infrastructural resources; create an open and flexible environment to respond quickly to new developments within and outside of Region V; monitor progress of all GLRCE activities toward their goals; recruit qualified women and minorities into biodefense research; and remain responsive to the needs of all its constituencies, ranging from basic research, to medical research to first responders. The organization of the core links investigators with pharmaceutical and biotech companies, as well as federal, state and local agencies to foster translational research and promote maximal use of the core facilities. The GLRCE has defined mechanisms for monitoring and self-evaluation of its research activities, as well as identifying and responding to new opportunities. In case of a biodefense emergency, the GLRCE administrative core will rapidly realign its activities and resources to assist local and national response efforts and facilitate fluent communications with its participants and their respective communities. The committee based management scheme of the GLRCE, and its web-based collaboration tools will ensure information flow from top to bottom and vice-versa. RELEVANCE: The core is designed to assure financial and administrative integrity of the GLRCE and all of its affiliated institutions. The purpose of the core is to maintain scientific objective and bias-free direction and coordination of the projects; enable the RCE management to identify opportunities and to attract intellectual and infrastructural resources.