Career Development Project Competition

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B.3.c. Career Development Projects (CDP). Two programs of the Midwestem RCE will further the training of scientists in biodefense and emerging infectious diseases. Research topics pursued by trainees must be focused on anthrax, botulism, hemorrhagic fever, plague, smallpox or tularemia with the intent of (i) developing therapeutics, (ii) vaccines, (iii) diagnostic devices or (iv) advancing basic knowledge of the mechanisms of disease. The first program is comprised of three faculty awards intended to focus the career of junior or established faculty on biodefense research. As outlined by NIAID, at least one of three CDPs must be focused on basic science, and at least one on translational/clinical science. The scope and expectations of CDP projects resembles that of N/H First Awards, or Doris Duke Foundation and Howard Hughes Awards, which are dissimilar to current T, K and F NIH awards in that they encourage interested scientists with potential but limited previous NIH-funded awards/grants. Funding for CDPs is limited to $110,000 direct costs per year with a total limit of three years of funding. CDPs are additionally supported by Core Projects (CPI-10, see below) adding shared value to RP, DP and CDP investigators in the Midwestem RCE. Trainees are guided by established investigators of the Midwestem RCE and inter-institutional and/or inter-disciplinary mentorships are strongly encouraged. Listed below are three CDPs that have been selected for proposal submission during EB review of proposals submitted in response to the Midwestem RCE RFA. CDP funding will be initiated for a period of one year and is subject to annual competitive review and renewal. During the review of CDPs, the outcome measures of science and training for Midwestem RCE scientists will be applied (see B.4. for detail). The review criteria for Midwestem RCE proposals are described in section A.2.c. CDPI" Professor Teresa Zembower (NU) will conduct phase 1/11open-label study analyzing the clinical and immunologic effects of smallpox vaccination and the local shedding of vaccinia virus in healthy volunteers who receive Dryvax ¿ with or without tenofovir. Dr. Zembower will be guided by Professor Gregory Poland (MC). CDP2: Dr. Liaohai Chert, on the faculty of the Biosciences Division at ANL, will develop an early detection system for hemorrhagic fever viruses by affinity imprinting of single viral particles. Dr. Chert will be mentored by Professor Richard Kuhn (PU). CDP3: Professor Joanna Shisler (UIUC) will examine the regulatory mechanisms of poxviridae on NF-KB mediated regulation of the host immune response. Professor Shisler will be guided by Professor Paula Traktman (MCW). CDP4: The second program is comprised of five Research Associate Training Awards (RATA) to be awarded each year. Funding is for NIH level salary and laboratory support of post-doctoral trainees - no more than $40,000 direct costs for a total of one year. RATAs are awarded in conjuction with EB proposal review of trainee, trainee scientific proposal and research mentor and are described in detail in D.