Cold Spring Harbor Laboratory Faculty Recruitment in Developmental Neurobiology

冷泉港实验室发育神经生物学教师招聘

• 批准号: 7859566
• 负责人: ANTHONY M ZADOR
• 金额: $ 71.9万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7859566
• 关键词: Affect; Area; Autistic Disorder; Biological; Biology; Bipolar Disorder; Brain; Chromosomes; Chronic; Complement; Complex; Development; Diagnosis; Disease; Engineering; Faculty; Gene Dosage; Genetic; Genetic Variation; Genomics; Knowledge; Laboratories; Modeling; Mus; Neurosciences; Physiology; Recruitment Activity; Role; Schizophrenia; Scientist; Synapses; System; Translating; Variant; cognitive neuroscience; developmental neurobiology; improved; innovation; interest; mouse model; multidisciplinary; neural circuit; neuropsychiatry; programs; public health relevance

DESCRIPTION (provided by applicant): Cold Spring Harbor Laboratory (CSHL) is seeking support to recruit a developmental neurobiologist with knowledge and expertise in neural circuit development and plasticity to significantly enhance current efforts to understand how neuropsychiatric disorders affect brain function. This scientist will be part of an innovative and multidisciplinary team that combines genetics, mouse models and neuroscience to study the underlying biology contributing to disorders such as schizophrenia, bipolar disorder and autism. The team is building on groundbreaking efforts by the genetics group at CSHL who have contributed significantly to the field's understanding of genetic variations underlying these disorders. As this group continues to identify new variants associated with disease, including the emerging role of variations in gene copy number, another group at CSHL is using chromosome engineering to model these large genomic duplications and deletions in the mouse. Finally, CSHL neuroscientists are using these mice to determine how these disease-related variants affect brain function. Currently, the neuroscience group at CSHL includes expertise in synaptic physiology, analysis of neural circuits and systems, and cognitive neuroscience. A developmental neurobiologist, with particular interest and expertise in neural circuit development and plasticity, would provide the ideal complement to the team we are building, and recruitment in this area is the highest priority for CSHL. Public Health Relevance: By successfully recruiting a developmental neurobiologist to its program, the CSHL team will be poised to translate genetic discoveries into a better understanding of the biological underpinnings of autism, schizophrenia and bipolar disorder. This, in turn, will facilitate further discoveries for improving the treatment and diagnosis of these complex and chronic conditions.

描述（申请人提供）：冷泉港实验室（CSHL）现招聘一名具有神经回路发育和可塑性知识和专业知识的发育神经生物学家，以显著加强目前对神经精神疾病如何影响大脑功能的研究。这位科学家将成为一个创新的多学科团队的一员，该团队将遗传学、小鼠模型和神经科学结合起来，研究导致精神分裂症、双相情感障碍和自闭症等疾病的潜在生物学。该团队是在CSHL遗传学小组的开创性努力的基础上建立的，他们对该领域对这些疾病背后的遗传变异的理解做出了重大贡献。随着这个小组继续确定与疾病相关的新变异，包括基因拷贝数变异的新作用，CSHL的另一个小组正在使用染色体工程在小鼠中模拟这些大的基因组复制和缺失。最后，CSHL的神经科学家正在用这些老鼠来确定这些与疾病相关的变异是如何影响大脑功能的。目前，CSHL的神经科学小组包括突触生理学，神经回路和系统分析以及认知神经科学方面的专业知识。一位对神经回路发育和可塑性有特别兴趣和专业知识的发育神经生物学家，将为我们正在建立的团队提供理想的补充，CSHL在这一领域的招聘是最优先考虑的。