Effects of Prenatal Alcohol Exposure at 22 Years

22 岁时产前接触酒精的影响

基本信息

批准号：
7631049
负责人：
NANCY Lee DAY
金额：
$ 17.99万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-20 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7631049
关键词：
Adolescence Adolescent Adult Affect African American Age Alcohol consumption Alcohol or Other Drugs use Alcohols Arousal Attention Beer Behavior Behavioral Behavioral inhibition Belief Caucasians Caucasoid Race Characteristics Child Childhood Clinic Cognitive Cognitive deficits Data Data Analyses Data Set Development Diagnosis Diagnostic Dose Drug usage Employment Environment Family Fetal Alcohol Exposure Fetal Alcohol Syndrome Frequencies Funding Growth Household Infant Interview Lead Learning Light Long-Term Effects Marijuana Measures Mediator of activation protein Memory Modeling Morphology Mothers National Institute on Alcohol Abuse and Alcoholism Neuraxis Occupational Occupations Outcome Parenting behavior Pattern Performance Phase Population Pregnancy Pregnancy Trimesters Pregnant Women Problem behavior Protocols documentation Psychiatric Diagnosis Regulation Role Shapes Sleep Social Problems Symptoms Theoretical model Time Tobacco Wine Woman age effect alcohol exposure binge drinking cell motility cohort distilled alcoholic beverage drinking early onset executive function eye hand coordination feeding fetal marijuana exposure infancy male men neuropsychological offspring prenatal primary outcome psychologic public health relevance response secondary outcome social

项目摘要

DESCRIPTION (provided by applicant): From childhood through adolescence, we have found that prenatal alcohol exposure (PAE) predicts deficits in growth, morphology, and CNS development, the three domains that define Fetal Alcohol Syndrome. We have found these effects across the spectrum of alcohol use, demonstrating that PAE has significant effects at light, moderate, and high levels of exposure. This is particularly important to document in light of the still widespread belief that low-level alcohol consumption by pregnant women is safe. The majority of the women in our cohort drank at light and moderate levels, although we had drinkers across the spectrum of alcohol use. The number of low and moderate drinkers in our cohort has uniquely allowed us to identify the effects of low and moderate levels of alcohol exposure during gestation in addition to the effects of high levels of alcohol use, abuse, and binge drinking. Having data across the spectrum of use also gives us the ability to define the shape of the relations between PAE and the outcomes and to explore whether these associations are best modeled as dose-response or threshold relations. This proposal is to analyze data on the offspring and their mothers when the offspring are age 22. We will identify the effects of PAE at age 22, and we will integrate the 22-year assessment with the prior 10 phases to look at the trajectories of development from gestation through infancy, childhood, adolescence, and young adulthood. PUBLIC HEALTH RELEVANCE: Prenatal alcohol exposure has significant effects on the development of the central nervous system, growth, and morphology. At high levels of exposure, effects across these three domains lead to Fetal Alcohol Syndrome. Little is known about the effects of lower levels of alcohol exposure during gestation. This is a proposal to identify the effects of low and moderate, as well as heavy levels of prenatal alcohol exposure.

描述（由申请人提供）：从童年到青春期，我们发现产前酒精暴露（PAE）可以预测生长，形态和CNS发育的缺陷，这是定义胎儿酒精综合征的三个领域。我们已经在饮酒范围内发现了这些影响，表明PAE在光，中等和高水平的暴露量下具有显着影响。鉴于仍然普遍认为，孕妇的低水平饮酒是安全的，这一点尤其重要。我们队列中的大多数妇女在轻度和中等水平上喝酒，尽管我们在饮酒范围内饮酒。我们队列中的低饮酒者和中等饮酒者的数量唯一允许我们在妊娠期间识别低酒精含量和中等水平的酒精暴露的影响，除了高水平的酒精使用，滥用和暴饮暴食的影响。在整个使用范围内拥有数据也使我们能够定义PAE与结果之间关系的形状，并探索这些关联是否最好地建模为剂量响应或阈值关系。该建议是在后代年龄22岁时分析后代及其母亲的数据。我们将确定22岁的PAE的影响，我们将将22年评估的影响与前10个阶段相结合，以查看从妊娠到婴儿，童年，青少年，青春期，青春期和年轻的春季的发展轨迹。公共卫生相关性：产前酒精暴露对中枢神经系统，生长和形态的发展具有重大影响。在高水平的暴露量下，这三个领域的影响导致胎儿酒精综合征。关于妊娠期间酒精暴露水平较低的影响知之甚少。这是一项建议，以确定低和中等的影响以及大量的产前酒精暴露。