Effects of Prenatal Alcohol Exposure at 22 Years

描述（由申请人提供）：从儿童期到青春期，我们发现产前酒精暴露（PAE）可预测生长、形态和CNS发育的缺陷，这三个领域定义了胎儿酒精综合征。我们已经发现了这些影响在整个范围内的酒精使用，表明PAE具有显着的影响，在轻，中度和高水平的暴露。鉴于人们仍然普遍认为孕妇少量饮酒是安全的，这一点尤其重要。在我们的队列中，大多数女性都在轻度和中度饮酒，尽管我们的饮酒者跨越了酒精使用的范围。在我们的队列中，低和中度饮酒者的数量独特地使我们能够确定妊娠期间低和中度酒精暴露的影响，以及高水平酒精使用，滥用和酗酒的影响。拥有整个使用范围的数据也使我们能够定义PAE与结果之间关系的形状，并探索这些关联是否最好建模为剂量-反应或阈值关系。这项建议是在后代22岁时分析后代及其母亲的数据。我们将在22岁时确定PAE的影响，并将22年的评估与之前的10个阶段相结合，以查看从妊娠到婴儿期，儿童期，青春期和青年期的发展轨迹。公共卫生相关性：产前酒精暴露对中枢神经系统的发育、生长和形态有显着影响。在高水平的接触下，这三个领域的影响导致胎儿酒精综合征。人们对妊娠期低水平酒精暴露的影响知之甚少。这是一个建议，以确定影响低，中度，以及大量的产前酒精暴露。

DESCRIPTION (provided by applicant): From childhood through adolescence, we have found that prenatal alcohol exposure (PAE) predicts deficits in growth, morphology, and CNS development, the three domains that define Fetal Alcohol Syndrome. We have found these effects across the spectrum of alcohol use, demonstrating that PAE has significant effects at light, moderate, and high levels of exposure. This is particularly important to document in light of the still widespread belief that low-level alcohol consumption by pregnant women is safe. The majority of the women in our cohort drank at light and moderate levels, although we had drinkers across the spectrum of alcohol use. The number of low and moderate drinkers in our cohort has uniquely allowed us to identify the effects of low and moderate levels of alcohol exposure during gestation in addition to the effects of high levels of alcohol use, abuse, and binge drinking. Having data across the spectrum of use also gives us the ability to define the shape of the relations between PAE and the outcomes and to explore whether these associations are best modeled as dose-response or threshold relations. This proposal is to analyze data on the offspring and their mothers when the offspring are age 22. We will identify the effects of PAE at age 22, and we will integrate the 22-year assessment with the prior 10 phases to look at the trajectories of development from gestation through infancy, childhood, adolescence, and young adulthood. PUBLIC HEALTH RELEVANCE: Prenatal alcohol exposure has significant effects on the development of the central nervous system, growth, and morphology. At high levels of exposure, effects across these three domains lead to Fetal Alcohol Syndrome. Little is known about the effects of lower levels of alcohol exposure during gestation. This is a proposal to identify the effects of low and moderate, as well as heavy levels of prenatal alcohol exposure.