PRENATAL MARIJUANA EXPOSURE: LONG-TERM OUTCOMES

产前吸食大麻：长期结果

基本信息

批准号：
7176824
负责人：
NANCY Lee DAY
金额：
$ 47.74万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-02-15 至 2010-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7176824
关键词：
Achievement Affect African American Age Age-Years Alcohol or Other Drugs use Alcohols Anxiety Attention Behavior Behavioral Birth Brain Caucasians Caucasoid Race Child Child Development Clinic Cognition Cognitive DSM-IV Data Analyses Dependence Development Diagnosis Disease Electroencephalography Environment Exposure to Household Impulsivity Interview Lead Major Depressive Disorder Marijuana Maternal Health Measures Mediating Mental Depression Mental disorders Moods Outcome Pattern Performance Phase Pliability Population Pregnancy Progress Reports Psychiatric Diagnosis Rate Reporting Risk Factors Role Score Sleep Substance abuse problem Testing Time Tobacco use Woman cohort day executive function externalizing behavior fetal marijuana exposure male neuropsychological peer prenatal prenatal exposure programs psychologic research study response social visual memory young adult

项目摘要

DESCRIPTION (provided by applicant): The Maternal Health Practices and Child Development Project provides a unique opportunity to assess the development and maturation of young adults who have been followed since their fourth month of gestation through the age of 16. At this proposed phase, the offspring will be 21 years of age. We will explore the effects of prenatal marijuana exposure (PME) on the offspring in young adulthood. We will integrate this assessment with measures at prior phases and evaluate the developmental trajectories of these young adults across the multiple time points of the study. Importantly, at this proposed phase, we will assess the effects of prenatal exposure to marijuana on the transition into and adjustment to the roles and responsibilities of adulthood. The women in this project were interviewed in their fourth and seventh prenatal months and with their offspring at delivery, birth, 8 and 18 months, 3, 6, 10, 14 and 16 years of age. The cohort was selected from a prenatal clinic and the women represent the spectrum of prenatal marijuana use. At each of the 10 phases, we measured demographic status, the psychological, social, and household environment, maternal, paternal, and household substance use. We assessed the children's cognitive, behavioral, academic, psychological, physical, and neuropsychological status, and substance use and abuse. Study results to date demonstrate that marijuana exposure during gestation affects the development of the CNS, resulting in problems with mood, response suppression, and aspects of executive function. These outcomes, as well as the sequelae of these effects, such as academic difficulties and externalizing behaviors, may lead to more serious problems in adulthood. The deficits that result from prenatal exposure to marijuana have important implications for long-term development.

描述（由申请人提供）：孕产妇健康实践和儿童发展项目提供了一个独特的机会，可以评估自16岁以来妊娠四个月以来一直遵循的年轻人的发展和成熟。在这个拟议的阶段，后代将为21岁。我们将探讨产前大麻（PME）对成年后代的影响。我们将将这一评估与先前阶段的度量相结合，并评估这些年轻人在研究的多个时间点中的发展轨迹。重要的是，在这个拟议的阶段，我们将评估产前暴露于大麻对成年的角色和责任的过渡和调整的影响。该项目中的妇女在第四和第七个月份接受了采访，以及分娩时的后代，出生，8个月和18个月，3、6、10、14和16岁。该队列是从产前诊所中选择的，女性代表了产前大麻使用的范围。在这10个阶段的每个阶段中，我们都测量了人口统计，心理，社会和家庭环境，母亲，父亲和家用物质的使用。我们评估了儿童的认知，行为，学术，心理，身体和神经心理学的地位以及药物使用和虐待。迄今为止的研究结果表明，妊娠期间的大麻暴露会影响中枢神经系统的发展，从而导致情绪，反应抑制和执行功能方面的问题。这些结果以及这些影响的后遗症，例如学术困难和外在行为，可能会导致成年后更严重的问题。产前接触大麻的赤字对长期发展具有重要意义。