PRENATAL MARIJUANA EXPOSURE: LONG-TERM OUTCOMES

产妇保健做法和儿童发展项目提供了一个独特的机会来评估 从第四个月开始跟踪观察的年轻人的发育和成熟 怀孕到16岁。在这个拟议的阶段，后代将年满21岁。我们会 探讨产前大麻暴露(PME)对幼年子代的影响。我们会 将这一评估与先前阶段的措施相结合，并评估 这些年轻人跨越了研究的多个时间点。重要的是，在这个拟议的阶段，我们将 评估出生前接触大麻对角色转变和适应的影响 成年的责任。 该项目中的妇女在她们产前的第四个月和第七个月接受了采访，并与她们的 分娩时、出生时、8个月和18个月、3、6、10、14和16岁的后代。这群人是从 一家产前诊所和这些妇女代表了产前使用大麻的范围。在10个 _我们测量了人口状况，心理，社会和家庭环境，母亲， _妇女和家庭物质的使用。我们评估了孩子们的认知，行为，学习， -心理、身体和神经心理状况，以及药物使用和滥用。 到目前为止的研究结果表明，怀孕期间接触大麻会影响 中枢神经系统，导致情绪、反应抑制和执行功能方面的问题。这些 结果，以及这些影响的后遗症，如学业困难和外部化 行为，可能会导致成年后出现更严重的问题。因产前暴露而导致的缺陷 禁止吸食大麻对长期发展具有重要意义。

The Maternal Health Practices and Child Development Project provides a unique opportunity to assess Lhedevelopment and maturation of young adults who have been followed since their fourth month of gestation through the age of 16. At this proposed phase, the offspring will be 21 years of age. We will explore the effects of prenatal marijuana exposure (PME) on the offspring in young adulthood. We will integrate this assessment with measures at prior phases and evaluate the developmental trajectories of these young adults across the multiple time points of the study. Importantly, at this proposed phase, we will assess the effects of prenatal exposure to marijuana on the transition into and adjustment to the roles and responsibilities of adulthood. The women in this project were interviewed in their fourth and seventh prenatal months and with their offspring at delivery, birth, 8 and 18 months, 3, 6, 10, 14 and 16 years of age. The cohort was selected from a prenatal clinic and the women represent the spectrum of prenatal marijuana use. At each of the 10 _hases, we measured demographic status, the psychological, social, and household environment, maternal, _aternal, and household substance use. We assessed the children's cognitive, behavioral, academic, _sychological, physical, and neuropsychological status, and substance use and abuse. Study results to date demonstrate that marijuana exposure during gestation affects the development of the CNS, resulting in problems with mood, response suppression, and aspects of executive function. These outcomes, as well as the sequelae of these effects, such as academic difficulties and externalizing behaviors, may lead to more serious problems in adulthood. The deficits that result from prenatal exposure to marijuana have important implications for long-term development.