GENETIC AND EXPERIENTIAL FACTORS INFLUENCING FUNCTIONAL ORGANIZATION OF MOTOR

影响运动功能组织的遗传和经验因素

• 批准号: 7951037
• 负责人: STEVEN Michael CRAMER
• 金额: $ 3.91万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951037
• 关键词: Area; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Development; Exhibits; Financial compensation; Funding; Genetic; Grant; Image; Impairment; Institution; Location; Motor; Motor Cortex; Movement; Pattern; Performance; Recovery; Rehabilitation therapy; Research; Research Personnel; Residual state; Resources; Severities; Source; Stroke; Therapeutic Intervention; Tissues; United States National Institutes of Health; Upper Extremity; disability; improved; motor impairment; neuromechanism; post stroke; relating to nervous system; research study; restoration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Motor impairments represent the primary functional deficit observed following stroke. Over 80% of all stroke victims exhibit some form of movement disability with upper extremity impairments being the most common. Post stroke motor rehabilitation can often significantly improve motor function depending on the severity and location of the damage (Duncan et al., 2000). Although the specific neural mechanisms underlying motor recovery are unknown, recent neural imaging and cortical stimulation experiments have implicated functional compensation within residual neural tissue. Rehabilitation induced improvements in motor performance can alter both the pattern of cortical activity associated with movement (Cramer, 2002) and the locus of stimulation evoked movement representations within intact cortical tissue (Nudo et al., 1996; Kleim et al., 2003). Restoration of movement through motor rehabilitation may be supported by functional reorganization within intact motor areas. Understanding those factors contributing to the capacity for motor cortex reorganization will contribute to the development of putative therapeutic interventions for enhancing motor recovery after stroke.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 运动障碍代表中风后观察到的主要功能缺陷。超过80%的中风患者表现出某种形式的运动障碍，其中上肢障碍最常见。中风后运动康复通常可以显著改善运动功能，这取决于损伤的严重程度和位置（邓肯等人，2000）。虽然运动恢复的具体神经机制尚不清楚，但最近的神经成像和皮层刺激实验表明残留神经组织内存在功能补偿。康复诱导的运动表现的改善可以改变与运动相关的皮质活动的模式（Cramer，2002）和完整皮质组织内的刺激诱发的运动表征的位点（Nudo等人，1996; Kleim等人，2003年）。通过运动康复来恢复运动可以通过在完整的运动区域内的功能重组来支持。了解这些因素有助于运动皮层重组的能力，将有助于发展推定的治疗干预措施，以促进中风后的运动恢复。