EFFECTS OF DOPAMINE AND DOPAMINE RECEPTOR POLYMORPHISMS ON EXPERIENCE-DEPENDENT

多巴胺和多巴胺受体多态性对经验依赖性的影响

• 批准号: 8166936
• 负责人: STEVEN Michael CRAMER
• 金额: $ 3.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166936
• 关键词: Animals; Computer Retrieval of Information on Scientific Projects Database; Dopamine; Dopamine Receptor; Eligibility Determination; Funding; Genes; Genetic; Genetic Polymorphism; Genotype; Grant; Human; Institution; Learning; Levodopa; Marble; Measures; Motor Skills; Patients; Placebos; Randomized; Research; Research Personnel; Research Project Grants; Resources; Source; Time; Transcranial magnetic stimulation; United States National Institutes of Health; behavior measurement; experience; falls; improved; neurophysiology; skills training

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed research project will focus on three different polymorphisms in dopamine-related genes which alter the amount of available CNS dopamine. Subjects will initially be screened for TMS eligibility, and then for these dopamine-related polymorphisms. Subjects falling into the desired genotype groups will be invited to participate further. These subjects will participate in two randomized conditions, one in which the subject receives levodopa prior to motor skill training and one with a placebo. It is hypothesized that neurophysiological and behavioral measures that improve with experience-dependent activity will further improve when examined in the setting of increased CNS dopamine levels; and that this enhancement will vary in relation to dopamine receptor genotype. Studies with animals, healthy humans and patients provide evidence that these genes and polymorphisms are reasonably associated with the cortical plasticity being studied here, and therefore are good candidates for evaluating genetic influences. Dependent variables will be transcranial magnetic stimulation (TMS) measures of cortical plasticity and behavioral measures of learning, as characterized by time to completion and errors on a marble navigation task.

这个子项目是众多研究子项目之一