BIOPSYCHOSOCIAL BASES OF SOCIAL RESPONSES TO THREAT: STUDY 2

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标：这项研究的首要目标是确定有助于社会支持的健康益处的生物社会机制。 审查引起对外部威胁作出社会反应的动态生物-心理-社会过程。 ？审查这些过程中的性别差异，重点放在潜在的生物过程中的潜在性别差异。 阐明社会关系对威胁的生物、心理和社会反应产生有利或不利影响的机制。 更具体而言，我们会： 研究OT中自然海拔升高的心理和社会相关性，以复制和扩展我们之前的发现，即血浆OT升高与社会关系中的差距和问题有关。 确定提升的加班时间是否会成为寻求分支机构联系的动力。 检查OT升高是否会导致自主神经和HPA轴对压力的反应减少，并与积极的社会接触相结合。 检查OT升高是否会导致自主神经和HPA对压力的压力反应增强，并伴随着不支持的社会接触。 研究这些过程是否发生在男性和女性身上，并研究加压素(AVP)，一种与OT非常相似的神经肽，是否与男性对压力的社会反应有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: The overarching goal of the research is to identify biosocial mechanisms that contribute to the health benefits of social support. ¿ Examine the dynamic biopsychosocial processes that give rise to social responses to external threats. ¿ Examine gender differences in these processes with a focus on potential sex differences in underlying biological processes. ¿ Clarify the mechanisms by which social relationships beneficially or adversely affect biological, psychological, and social responses to threat. More specifically, we will: ¿ Examine the psychological and social correlates of natural elevations in OT in order to replicate and extend our previous findings that plasma OT is elevated in conjunction with gaps and problems in social relationships. ¿ Determine if elevated OT acts as an impetus to seek affiliative contact. ¿ Examine whether elevated OT leads to reduced autonomic and HPA axis responses to stress in conjunction with positive social contacts. ¿ Examine whether elevated OT leads to enhanced autonomic and HPA stress responses to stress in conjunction with unsupportive social contacts. ¿ Examine whether these processes occur in men as well as women and investigate whether vasopressin (AVP), a neuropeptide very similar to OT, may be implicated in men's social responses to stress.