BIOPSYCHOSOCIAL BASES OF SOCIAL RESPONSES TO THREAT: STUDY 2

对威胁的社会反应的生物心理社会基础：研究 2

• 批准号: 7718008
• 负责人: SHELLEY E TAYLOR
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718008
• 关键词: Affect; Biological; Biological Process; Biosocial; Computer Retrieval of Information on Scientific Projects Database; Elevation; Funding; Goals; Grant; HPSE gene; Health Benefit; Institution; Neuropeptides; Plasma; Process; Research; Research Personnel; Resources; Sex Characteristics; Social support; Source; Stress; United States National Institutes of Health; Vasopressins; Woman; base; biological adaptation to stress; biopsychosocial; hypothalamic-pituitary-adrenal axis; men; psychologic; response; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: The overarching goal of the research is to identify biosocial mechanisms that contribute to the health benefits of social support. ¿ Examine the dynamic biopsychosocial processes that give rise to social responses to external threats. ¿ Examine gender differences in these processes with a focus on potential sex differences in underlying biological processes. ¿ Clarify the mechanisms by which social relationships beneficially or adversely affect biological, psychological, and social responses to threat. More specifically, we will: ¿ Examine the psychological and social correlates of natural elevations in OT in order to replicate and extend our previous findings that plasma OT is elevated in conjunction with gaps and problems in social relationships. ¿ Determine if elevated OT acts as an impetus to seek affiliative contact. ¿ Examine whether elevated OT leads to reduced autonomic and HPA axis responses to stress in conjunction with positive social contacts. ¿ Examine whether elevated OT leads to enhanced autonomic and HPA stress responses to stress in conjunction with unsupportive social contacts. ¿ Examine whether these processes occur in men as well as women and investigate whether vasopressin (AVP), a neuropeptide very similar to OT, may be implicated in men's social responses to stress.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标：研究的总体目标是确定有助于社会支持的健康益处的生物社会机制。 ¿ 研究动态的生物心理社会过程，引起社会对外部威胁的反应。 ¿ 检查这些过程中的性别差异，重点是潜在的生物过程中的性别差异。 ¿ 阐明社会关系有利或不利地影响生物，心理和社会对威胁的反应的机制。 具体而言，我们将： ¿ 检查OT自然升高的心理和社会相关性，以复制和扩展我们以前的发现，即血浆OT与社会关系中的差距和问题一起升高。 ¿ 确定OT升高是否是寻求亲和联系的动力。 ¿ 检查OT升高是否会导致自主神经和HPA轴对压力的反应减少，以及积极的社会接触。 ¿ 检查OT升高是否会导致增强的自主神经和HPA应激反应，以及不支持的社会接触。 ¿ 检查这些过程是否发生在男性和女性身上，并调查加压素（AVP），一种与OT非常相似的神经肽，是否可能与男性对压力的社会反应有关。