GASTROPARESIS REGISTRY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 胃轻瘫是一种主要影响年轻妇女的毁灭性疾病。 胃轻瘫的症状特征包括恶心（90%的患者）、呕吐（>80%）、疼痛（~50%）、早饱（60%）和腹胀（75%），症状组合及其严重程度可能不同。由于其慢性且往往难以治愈的性质，这种疾病对患者和整个社会都有巨大的影响。胃轻瘫仍然很难治疗，很大程度上是因为缺乏对这种疾病潜在病理生理学的了解。特别是，有几个因素阻碍了这一领域的进展，包括任何一个中心看到的患者数量很少，缺乏统一的诊断标准，缺乏普遍可用的，可靠的方法进行生理测试和组织病理学相关性的不可及性。鉴于问题的复杂性，以及目前与这种疾病相关的发病率的深刻程度，迫切需要以系统的、协调一致的方式研究患者。这样的研究最好通过招募患者并从多个中心收集数据来实现，这些中心是专注于这种疾病的大型研究者网络的一部分。认识到这一事实，国家糖尿病、消化和肾脏疾病研究所（NIDDK）通过RFA DK 05 004机制，于2006年成立了胃轻瘫临床研究联盟。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gastroparesis is a devastating disease affecting predominantly young women. The symptomatic profile of gastroparesis includes nausea (90% of patients), vomiting (>80%), pain (~50%), early satiety (60%) and bloating (75%) and can vary in both the combination of symptoms and their severity. Because of its chronic, and often intractable nature, the disorder has a tremendous impact on both patients and society at large. Gastroparesis remains difficult to treat, in large part because of the lack of knowledge of the underlying pathophysiology of this disease. Several factors, in particular, have impeded the progress in this field including the paucity of patients seen by any one center, the absence of uniform diagnostic criteria, the lack of generally available, reliable methods for physiological testing and the inaccessibility of tissue for histopathological correlation. Given the complexity of the problem, and the profound degree of morbidity currently associated with this disorder, a compelling need exists to study patients in a systematic, concerted manner. Such studies can best be achieved by recruiting patients and collecting data from multiple centers as part of a large network of investigators focused on this disorder. In recognition of this fact, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the mechanism of RFA DK 05 004, established the Gastroparesis Clinical Research Consortium in 2006.