GASTROPARESIS REGISTRY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 胃瘫是一种毁灭性的疾病，主要影响年轻女性。胃瘫的症状包括恶心(90%的患者)、呕吐(80%)、疼痛(~50%)、早饱(60%)和腹胀(75%)，症状组合和严重程度各不相同。由于其慢性且往往难以治愈的性质，这种疾病对患者和整个社会都有巨大的影响。胃轻瘫仍然很难治疗，很大程度上是因为对这种疾病的基本病理生理学缺乏了解。尤其是，有几个因素阻碍了这一领域的进展，包括任何一个中心都看不到患者，缺乏统一的诊断标准，缺乏普遍可用的可靠的生理测试方法，以及无法获得组织病理对照。鉴于问题的复杂性，以及目前与这种疾病相关的严重发病率，迫切需要以系统、协调的方式对患者进行研究。这样的研究最好是招募患者，并从多个中心收集数据，作为专注于这种疾病的大型调查人员网络的一部分。认识到这一事实，国家糖尿病、消化和肾脏疾病研究所(NIDDK)通过RFA DK 05 004的机制，于2006年成立了胃瘫临床研究联盟。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gastroparesis is a devastating disease affecting predominantly young women. The symptomatic profile of gastroparesis includes nausea (90% of patients), vomiting (>80%), pain (~50%), early satiety (60%) and bloating (75%) and can vary in both the combination of symptoms and their severity. Because of its chronic, and often intractable nature, the disorder has a tremendous impact on both patients and society at large. Gastroparesis remains difficult to treat, in large part because of the lack of knowledge of the underlying pathophysiology of this disease. Several factors, in particular, have impeded the progress in this field including the paucity of patients seen by any one center, the absence of uniform diagnostic criteria, the lack of generally available, reliable methods for physiological testing and the inaccessibility of tissue for histopathological correlation. Given the complexity of the problem, and the profound degree of morbidity currently associated with this disorder, a compelling need exists to study patients in a systematic, concerted manner. Such studies can best be achieved by recruiting patients and collecting data from multiple centers as part of a large network of investigators focused on this disorder. In recognition of this fact, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the mechanism of RFA DK 05 004, established the Gastroparesis Clinical Research Consortium in 2006.