ICG

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究正在调查与美国(华盛顿特区、俄亥俄州克利夫兰)和尼日利亚(伊巴丹)基因研究中改善知情同意有关的问题。这将通过现有研究在华盛顿特区大都市区的一群非裔美国人中检测高血压的遗传流行病学来实现。具体目标是：(I)开发、测试和实施录像教育干预措施，以改善高血压和乳腺癌遗传流行病学研究的知情同意；(Ii)进行随机试验，以测试录像教育干预措施对两个结果的影响：a.对研究目标的理解和b.参与知情同意讨论，(Iii)审查关于基因研究对个人健康以及个人和群体身份的影响的信念，并确定其对个人参与基因研究的意愿和动机的影响，(Iv)提出建议，改进遗传流行病学研究的知情同意程序，以确保它们在文化上是适当的，为少数民族人口提供最大限度的信息和保护。参与者将被随机分成两组：(1)传统的同意方法和(2)采用常规同意程序的录像带教育干预。将使用观察性清单来评估参与者参与知情同意讨论的情况。随后将进行后续采访，一次在同意讨论后一周内进行，另一次在6-9个月后进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study is investigating issues related to improving informed consent in genetic research in the United States (Washington DC, Cleveland OH) and Nigeria (Ibadan). This will be done through existing studies examining the genetic epidemiology of hypertension in a cohort of African Americans in the Washington DC metropolitan area. The specific goals are to: (i) develop, test and implement a videotaped educational intervention to improve informed consent for genetic epidemiological research on hypertension and breast cancer, (ii) conduct a randomized trial to test the effect of the videotaped educational intervention on two outcomes: a. comprehension of research goals and b. participation during the informed consent discussion, (iii) examine beliefs about the implications of genetic research for personal health and individual and group identity, and determine their influence on individual's willingness and motive to participate in genetic research, (iv) develop recommendations to improve informed consent procedures for genetic epidemiological research to ensure that they are culturally appropriate, maximally informative and protective for ethnic populations. Participants will be randomized into one of two groups: (1) traditional approach to consent and (2) a videotaped educational intervention with the usual consent procedures. An observational checklist will be used to assess participants' participation in the informed consent discussion. Follow up interviews will then be done with pariticpants, one within one week of the consent discussion and the other 6-9 months afterwards.