PROGESTERONE INHIBITION OF GNRH PULSATILITY IN ADOLESCENT GIRLS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 青少年高雄激素血症似乎是成人多囊卵巢综合征（PCOS）的前兆。我们发现，PCOS成年女性对孕酮抑制GnRH脉动的敏感性降低。我们建议在正常和高雄激素血症的青春期女孩中检查孕酮对GnRH脉动的抑制，以确定这是否可能是高雄激素血症和最终PCOS的潜在原因。这些结果将有助于我们了解PCOS的原因，并可能导致预防性治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescent hyperandrogenemia appears to be a precursor to adult polycystic ovary syndrome (PCOS). We have found that adult women with PCOS have a reduced sensitivity to progesterone inhibition of GnRH pulsatility. We propose to examine progesterone inhibition of GnRH pulsatility in normal and hyperandrogenemic adolescent girls to determine whether this may be an underlying cause of hyperandrogenemia and eventually PCOS. The results will help us understand the causes of PCOS and may lead to preventative treatment.