PROGESTERONE INHIBITION OF GNRH PULSATILITY IN ADOLESCENT GIRLS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 青少年高雄激素血症似乎是成人多囊卵巢综合征(PCOS)的先兆。我们发现，患有多囊卵巢综合征的成年女性对孕激素抑制GnRH搏动性的敏感性降低。我们建议在正常和高雄激素血症的青春期女孩中检测孕酮对GnRH搏动性的抑制，以确定这是否可能是高雄激素血症并最终导致多囊卵巢综合征的潜在原因。这一结果将有助于我们了解多囊卵巢综合征的原因，并可能导致预防性治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescent hyperandrogenemia appears to be a precursor to adult polycystic ovary syndrome (PCOS). We have found that adult women with PCOS have a reduced sensitivity to progesterone inhibition of GnRH pulsatility. We propose to examine progesterone inhibition of GnRH pulsatility in normal and hyperandrogenemic adolescent girls to determine whether this may be an underlying cause of hyperandrogenemia and eventually PCOS. The results will help us understand the causes of PCOS and may lead to preventative treatment.