PROGESTERONE AND LH ACROSS PUBERTY IN GIRLS WITH/WITHOUT HYPERANDROGENEMIA

有/无高雄激素血症的女孩整个青春期的黄体酮和 LH

• 批准号: 8167186
• 负责人: John C Marshall
• 金额: $ 2万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167186
• 关键词: Adolescence; Adult; Androgens; Blood specimen; Computer Retrieval of Information on Scientific Projects Database; Disease; Estradiol; Female Adolescents; Frequencies; Funding; Grant; Hormonal; Hormones; Hour; Hyperandrogenism; Individual; Institution; Ovarian; Ovulation; Plasma; Progesterone; Puberty; Research; Research Personnel; Resources; Source; Syndrome; Testosterone; Time; United States National Institutes of Health; Work; girls

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The polycystic ovarian syndrome (PCOS) is a common disorder marked by irregular ovulation and hyperandrogenism. Hyperandrogenemia during adolescence can be a forerunner of adult PCOS. However, the progression of hormonal abnormalities leading to PCOS are unclear. We will examine hormonal profiles (e.g., LH, FSH, progesterone, testosterone, estradiol) during pubertal maturation in adolescent girls with and without elevated plasma androgens. The working hypothesis is that, in pubertal girls without hyperandrogenemia, overnight rises of P are associated with a reduction of LH frequency during the waking morning hours. However, in pubertal girls with hyperandrogenemia, LH frequency will be higher than normal during both the day and night, despite similar or higher P levels. The studies will involve frequent blood sampling over 18 hours. We will assess differences in hormone parameters between time blocks (1900-2300 h, 2300-0300 h, 0300-0700 h, 0700-1100 h) in individuals to evaluate diurnal changes. We will compare such changes between those with hyperandrogenemia and those without hyperandrogenemia.

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