PROGESTERONE AND LH ACROSS PUBERTY IN GIRLS WITH/WITHOUT HYPERANDROGENEMIA

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 多囊卵巢综合征（PCOS）是一种以排卵不规律和高雄激素血症为特征的常见疾病。青春期高雄激素血症可能是成年PCOS的先兆。然而，激素异常导致PCOS的进展尚不清楚。我们将检查荷尔蒙概况（例如，LH，FSH，孕酮，睾酮，雌二醇）在青春期成熟的青春期女孩和不升高的血浆雄激素。工作假设是，在青春期女孩没有高雄激素血症，夜间上升的P与LH频率在清醒的早晨时间减少。然而，在青春期女孩高雄激素血症，LH频率将高于正常在白天和晚上，尽管类似或更高的P水平。这些研究将包括在18小时内频繁采血。我们将评估个体在不同时间段（1900-2300 h，2300-0300 h，0300-0700 h，0700-1100 h）之间激素参数的差异，以评估昼夜变化。我们将比较高雄激素血症和非高雄激素血症患者的这些变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The polycystic ovarian syndrome (PCOS) is a common disorder marked by irregular ovulation and hyperandrogenism. Hyperandrogenemia during adolescence can be a forerunner of adult PCOS. However, the progression of hormonal abnormalities leading to PCOS are unclear. We will examine hormonal profiles (e.g., LH, FSH, progesterone, testosterone, estradiol) during pubertal maturation in adolescent girls with and without elevated plasma androgens. The working hypothesis is that, in pubertal girls without hyperandrogenemia, overnight rises of P are associated with a reduction of LH frequency during the waking morning hours. However, in pubertal girls with hyperandrogenemia, LH frequency will be higher than normal during both the day and night, despite similar or higher P levels. The studies will involve frequent blood sampling over 18 hours. We will assess differences in hormone parameters between time blocks (1900-2300 h, 2300-0300 h, 0300-0700 h, 0700-1100 h) in individuals to evaluate diurnal changes. We will compare such changes between those with hyperandrogenemia and those without hyperandrogenemia.