ANDROGEN RECEPTOR CAG REPEAT POLYMORPHISM AND SERUM ANDROGEN IN ADOLESCENT GIRLS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 青少年高雄激素血症似乎是成人多囊卵巢综合征(PCOS)的先兆。与多囊卵巢综合征一样，青少年高雄激素血症的病因尚不清楚。雄激素受体包含CAG重复长度多态，它赋予可变的雄激素受体反式激活活性。一些研究表明，雄激素受体CAG重复长度较短与女性睾酮水平升高之间存在联系；然而，这还没有在普通青少年人群中进行探索。我们假设高雄激素血症的青春期女孩的雄激素受体重复长度比正常对照组短，并且由于更高的雄激素水平和更高的雄激素敏感性，雄激素受体CAG重复长度短的女孩将有更明显的高雄激素表型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescent hyperandrogenemia appears to be a precursor to adult polycystic ovary syndrome (PCOS). As with PCOS, the etiology of adolescent hyperandrogenemia is not known. The androgen receptor contains a CAG repeat length polymorphism which confers variable androgen receptor transactivation activity. Some studies have suggested a link between short androgen receptor CAG repeat lengths and increased testosterone levels in females; this has not however yet been explored in the general adolescent population. We hypothesize that hyperandrogenemic adolescent girls have shorter androgen receptor repeat lengths than normal controls, and that as a consequence of higher androgen levels and increased androgen sensitivity, girls with short androgen receptor CAG repeat lengths will have a more pronounced hyperandrogenic phenotype.