PROGESTERONE AND LH ACROSS PUBERTY IN GIRLS WITH/WITHOUT HYPERANDROGENEMIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 多囊卵巢综合征(PCOS)是一种以排卵不规律和高雄激素血症为特征的常见疾病。青春期高雄激素血症可能是成人多囊卵巢综合征的先兆。然而，导致多囊卵巢综合征的激素异常的进展尚不清楚。我们将检测在青春期成熟期间有或没有血浆雄激素升高的女孩的激素谱(例如，黄体生成素、卵泡刺激素、孕酮、睾酮、雌二醇)。我们假设，在没有高雄激素血症的青春期女孩中，一夜之间P的升高与清醒的早晨的黄体生成素频率降低有关。然而，在患有高雄激素血症的青春期女孩中，黄体生成素的频率在白天和晚上都会高于正常水平，尽管P水平相似或更高。这些研究将涉及超过18小时的频繁采血。我们将评估不同时间段(1900-2300h，2300-0300h，0300-0700h，0700-1100h)之间激素参数的差异，以评估日变化。我们将比较高雄激素血症患者和非高雄激素血症患者之间的这种变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The polycystic ovarian syndrome (PCOS) is a common disorder marked by irregular ovulation and hyperandrogenism. Hyperandrogenemia during adolescence can be a forerunner of adult PCOS. However, the progression of hormonal abnormalities leading to PCOS are unclear. We will examine hormonal profiles (e.g., LH, FSH, progesterone, testosterone, estradiol) during pubertal maturation in adolescent girls with and without elevated plasma androgens. We hypothesize that in pubertal girls without hyperandrogenemia, overnight rises of P are associated with a reduction of LH frequency during the waking morning hours. However, in pubertal girls with hyperandrogenemia, LH frequency will be higher than normal during both the day and night, despite similar or higher P levels. The studies will involve frequent blood sampling over 18 hours. We will assess differences in hormone parameters between time blocks (1900-2300 h, 2300-0300 h, 0300-0700 h, 0700-1100 h) in individuals to evaluate diurnal changes. We will compare such changes between those with hyperandrogenemia and those without hyperandrogenemia.