NBP

NBP

• 批准号: 7951429
• 负责人: THOMAS A MELLMAN
• 金额: $ 0.19万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951429
• 关键词: Adrenergic Receptor; Anger; Blood; Blood Pressure; Blood Pressure Monitors; Cardiovascular system; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Consent; Discrimination; Evaluation; Event; Exposure to; Funding; Genetic Polymorphism; Grant; Institution; Link; Measures; Medical History; Participant; Patient Self-Report; Phase; Post-Traumatic Stress Disorders; Prejudice; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Resources; Role; Severities; Sleep; Source; Symptoms; Toxicology; Trauma; United States National Institutes of Health; Universities; Urine; blood pressure regulation; depressive symptoms; experience; healthy volunteer; meetings; salt intake; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed study aims investigate candidate mechanisms for linking PTSD to cardiovascular regulation and, in particular, the role of nocturnal blood pressure regulation along with hypothesized modifiers of the relationship of trauma exposure and nocturnal blood pressure including the role of trait anger and exposure to prejudice and discrimination. In a subsequent phase of the research we will also evaluate relationships to genetic polymorphisms of adrenergic receptors. Healthy volunteers and people who report having experinced a traumatic event and current endorse experiencing PTSD symptoms will be recruited to participate in the study. During their initial evaluation, all participants will complete self-report measures which assess for trauma exposure and PTSD related symptoms, depression, experiences of discrimination and prejudice, anger management, sensitivity of negative events, orientation towards pleasing others, dietary salt intake, and personal and medical history. Following initial assessment, consenting participants who meet criteria will complete a clinical review to further assess for intensity and severity of PTSD symptoms, physical exam and urine toxicology screen, overnight sleep recording, monitoring of blood pressure and activity level, and , in a subsequent phase of the research, a blood draws.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 拟议的研究旨在研究将PTSD与心血管调节联系起来的候选机制，尤其是夜间血压调节的作用以及假设的创伤暴露与夜间血压关系的修饰符，包括特征愤怒的作用以及对偏见和歧视的特质愤怒的作用。在随后的研究阶段，我们还将评估与肾上腺素能受体的遗传多态性的关系。 健康的志愿者和报告进行了经历过创伤事件和当前经历过PTSD症状的当前认可的人参加研究。在初步评估期间，所有参与者将完成自我报告措施，以评估创伤暴露和PTSD相关的症状，抑郁症，歧视和偏见的经历，愤怒管理，负面事件的敏感性，对他人取悦他人的敏感性，饮食盐的摄入量以及个人和个人和病史。经过初步评估后，符合标准的同意参与者将完成临床审查，以进一步评估PTSD症状，身体检查和尿液毒理学筛查的强度和严重程度，过夜睡眠记录，监测血压和活动水平，以及在随后的研究阶段，血液抽血。