CRYSTAL STRUCTURE OF YEAST MITOCHONDRIA TRANSLOCON MEMBER TIM50

酵母线粒体转运蛋白 TIM50 的晶体结构

• 批准号: 7955583
• 负责人: BINGDONG SHA
• 金额: $ 2.41万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955583
• 关键词: Biogenesis; Cells; Complex; Computer Retrieval of Information on Scientific Projects Database; Cytosol; Funding; Grant; Institution; Membrane; Membrane Proteins; Mitochondria; N-terminal; Play; Protein translocation; Research; Research Personnel; Resources; Role; Source; Structure; United States National Institutes of Health; Yeasts; member; protein transport; receptor; translocase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Protein translocations across mitochondria membranes play critical roles in mitochondria biogenesis. The protein transports from the cell cytosol to the mitochondria matrix are carried out by the translocase of the outer membrane (TOM) complex and the translocase of the inner membrane (TIM) complex. In the TIM23 translocon, Tim50 functions as a receptor to guide the precursor with the N-terminal mitochondrion targeting sequence to the inner membrane protein channel for translocation. Recently we have crystallized yeast Tim50. The crystallographic studies on yeast TIM23 translocon will uncover the basic mechanisms how the translocons facilitate the protein translocations across the mitochondria outer and inner membranes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 线粒体膜的蛋白质易位在线粒体生物发生中起关键作用。蛋白质从细胞胞质到线粒体基质的转运是由外膜（TOM）复合物的易位酶和内膜（TIM）复合物的易位酶进行的。 在TIM23转运中，TIM50充当受体，可引导前体，其n末端线粒体靶向序列是内膜蛋白通道以进行易位。最近，我们结晶了酵母TIM50。酵母TIM23转运的晶体学研究将发现基本机制如何促进线粒体外膜和内膜的蛋白质易位。