CRYSTAL STRUCTURE OF YEAST MITOCHONDRIA TRANSLOCON MEMBER TIM50

酵母线粒体转运蛋白 TIM50 的晶体结构

• 批准号: 7955583
• 负责人: BINGDONG SHA
• 金额: $ 2.41万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955583
• 关键词: Biogenesis; Cells; Complex; Computer Retrieval of Information on Scientific Projects Database; Cytosol; Funding; Grant; Institution; Membrane; Membrane Proteins; Mitochondria; N-terminal; Play; Protein translocation; Research; Research Personnel; Resources; Role; Source; Structure; United States National Institutes of Health; Yeasts; member; protein transport; receptor; translocase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Protein translocations across mitochondria membranes play critical roles in mitochondria biogenesis. The protein transports from the cell cytosol to the mitochondria matrix are carried out by the translocase of the outer membrane (TOM) complex and the translocase of the inner membrane (TIM) complex. In the TIM23 translocon, Tim50 functions as a receptor to guide the precursor with the N-terminal mitochondrion targeting sequence to the inner membrane protein channel for translocation. Recently we have crystallized yeast Tim50. The crystallographic studies on yeast TIM23 translocon will uncover the basic mechanisms how the translocons facilitate the protein translocations across the mitochondria outer and inner membranes.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 蛋白质跨线粒体膜转运在线粒体生物合成中起着关键作用。蛋白质从细胞质转运到线粒体基质是通过外膜复合物转位酶（translocase of outer membrane，TOM）和内膜复合物转位酶（translocase of inner membrane，TIM）完成的。 在TIM 23易位子中，Tim 50作为受体发挥功能，以引导具有N-末端双链体靶向序列的前体进入内膜蛋白通道进行易位。最近我们有结晶酵母Tim 50。对酵母TIM 23易位子的晶体学研究将揭示其促进蛋白质跨线粒体外膜和内膜易位的基本机制。