RIBOSOME SECY PROTEIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 内质网(ER)的核糖体通道复合体(RCC)负责内质网和高尔基体的分泌和驻留蛋白进入内质网的管腔，而膜蛋白则横向进入膜平面(Johnson和van Waes，1999)。因此，RCC负责人类所有膜蛋白的适当生物发生。 SecY复合体与核糖体结合形成细菌质膜中的蛋白质转位通道，而Sec61复合体在真核生物的内质网中起着类似的作用(Johnson和Van Waes，1999)。波士顿大学医学院的克里斯·阿基的团队与哈佛医学院的汤姆·拉波波特合作研究了这两个渠道。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ribosome channel complex (RCC) of the endoplasmic reticulum (ER) is responsible for the translocation of secretory and resident proteins of the ER and Golgi into the lumen of the ER, while membrane proteins are gated laterally into the plane of the membrane (Johnson and van Waes, 1999). Thus, the RCC is responsible for the proper biogenesis of all membrane proteins in humans. The SecY complex associates with the ribosome to form a protein translocation channel in the bacterial plasma membrane while the Sec61 complex plays a similar role in the endoplasmic reticulum in eukaryotes (Johnson and van Waes, 1999). Both of these channels were studied by Chris Akey's group at BU Medical School in collaboration with Tom Rapoport at Harvard Medical School.