RIBOSOME SECY PROTEIN

核糖体安全蛋白

• 批准号: 8361111
• 负责人: CHRISTOPHER W AKEY
• 金额: $ 1.23万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361111
• 关键词: Biogenesis; Cell membrane; Collaborations; Complex; Electron Microscopy; Endoplasmic Reticulum; Eukaryota; Funding; Golgi Apparatus; Grant; Human; Membrane; Membrane Proteins; National Center for Research Resources; Play; Principal Investigator; Protein translocation; Proteins; Research; Research Infrastructure; Resources; Ribosomes; Role; Source; United States National Institutes of Health; cost; macromolecule; medical schools

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The ribosome channel complex (RCC) of the endoplasmic reticulum (ER) is responsible for the translocation of secretory and resident proteins of the ER and Golgi into the lumen of the ER, while membrane proteins are gated laterally into the plane of the membrane (Johnson and van Waes, 1999). Thus, the RCC is responsible for the proper biogenesis of all membrane proteins in humans. The SecY complex associates with the ribosome to form a protein translocation channel in the bacterial plasma membrane while the Sec61 complex plays a similar role in the endoplasmic reticulum in eukaryotes (Johnson and van Waes, 1999). Both of these channels were studied by Chris Akey's group at BU Medical School in collaboration with Tom Rapoport at Harvard Medical School.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 内质网的核糖体通道复合体(RCC)负责 内质网和高尔基体的分泌和驻留蛋白移位到小鼠的管腔内 呃，而膜蛋白被横向选通到膜平面(约翰逊 和Van Waes，1999)。因此，RCC负责所有生物的适当生物发生 人类体内的膜蛋白。 SecY复合体与核糖体结合形成蛋白质转位通道。 细菌质膜，而Sec61复合体在 真核生物中的内质网(Johnson和van Waes，1999)。这两个渠道 是由BU医学院的克里斯·阿基的团队与汤姆·拉波波特合作进行的 在哈佛医学院。