CORRELATION OF T1? MRI AND SODIUM MRI IN INTERVERTEBRAL DISCS

T1 的相关性？

• 批准号: 7955338
• 负责人: CHENYANG WANG
• 金额: $ 1.67万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955338
• 关键词: Affect; Cations; Cattle; Charge; Clinical; Computer Retrieval of Information on Scientific Projects Database; Diagnostic Procedure; Funding; Grant; Institution; Intervertebral disc structure; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Population; Proteoglycan; Protons; Relaxation; Research; Research Personnel; Resources; Sampling; Sodium; Source; Staging; Time; United States National Institutes of Health; Water; Weight; density; in vivo; intervertebral disk degeneration; macromolecule; nucleus pulposus; optical imaging; progesterone 11-hemisuccinate-(2-iodohistamine)

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Intervertebral disc degeneration is a common and sometimes debilitating condition affecting a significant percentage of the population. The earliest stage of disc degeneration involves the breakdown of proteoglycans in the nucleus pulposus region of the disc. The current diagnostic method for disc degeneration relies on T2 -weighted proton MRI, which is not sensitive to proteoglycan breakdown. T1¿ MRI has been shown to be sensitive to the interaction between large macromolecules like the proteoglycan and bulk water, thus it is potentially sensitive to the proteoglycan concentration in IVD. Sodium MRI has been shown to be an accurate measurement of proteoglycan content, since Na+ cations are attracted by the fixed-charge density of the proteoglcyan molecules. The purpose of this study is to demonstrate T1¿ as a measurement of disc PG content, by correlating T1¿ relaxation time constants with [Na+] using self-coregistered proton T1¿ and sodium MR images of ex vivo bovine disc samples. Since sodium MRI has limited application in clinical settings due to the inherent low SNR and hardware requirement, T1¿ MRI may serve as a more suitable approach to non-invasive assessment of disc proteoglycan content in vivo.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 椎间盘退变是一种常见的，有时使人衰弱的疾病， 占人口的很大比例。椎间盘退变的最早阶段涉及 椎间盘髓核区域的蛋白多糖的分解。目前的诊断 用于椎间盘退变的方法依赖于T2加权质子MRI，其对 蛋白聚糖分解T1 <$MRI已被证明是敏感的相互作用， 大的大分子，如蛋白聚糖和大量的水，因此它是潜在的敏感性， IVD中的蛋白聚糖浓度。钠MRI已被证明是一个准确的测量 蛋白多糖含量的增加，因为Na+阳离子被蛋白多糖的固定电荷密度吸引， 蛋白聚糖分子。本研究的目的是证明T1 <$作为测量 盘PG内容，通过使用自配准的T1 <$弛豫时间常数与[Na+]相关 离体牛椎间盘样本的质子T1和钠MR图像。由于钠MRI限制了 由于固有的低SNR和硬件要求，T1 ² MRI在临床环境中的应用 可以作为一种更合适的方法，非侵入性评估椎间盘蛋白多糖含量 in vivo.