NON-INVASIVE MEASUREMENT OF INTERVERTEBRAL DISC OSMOTIC PRESSURE WITH T1P MRI

使用 T1P MRI 无创测量椎间盘渗透压

• 批准号: 8361968
• 负责人: CHENYANG WANG
• 金额: $ 3.08万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361968
• 关键词: Affect; Biomechanics; Cations; Cell Nucleus; Charge; Clinical; Fibrocartilages; Funding; Grant; Hydrostatic Pressure; Intervertebral disc structure; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; National Center for Research Resources; Noise; Osmotic Pressure; Population; Principal Investigator; Procedures; Property; Proteoglycan; Protocols documentation; Protons; Relaxation; Research; Research Infrastructure; Resources; Sampling; Signal Transduction; Sodium; Source; Staging; Techniques; Time; Tissues; United States National Institutes of Health; articular cartilage; clinical application; cost; density; intervertebral disk degeneration; nucleus pulposus; optical imaging; pressure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Intervertebral disc degeneration is a common and sometimes debilitating condition affecting a significant percentage of the population. The earliest stage of disc degeneration involves the breakdown and subsequent depletion of proteoglycans in the nucleus pulposus region of the disc, which results in decreased hydrostatic pressure in discs. Sodium MRI has previously been used to calculate the fixed-charge-density of the nucleus tissue, which can subsequently be used to calculate the osmotic pressure generated by the sodium cations attracted by the fixed-charge on proteoglycans. The osmotic pressure of intervertebral disc is linearly related to the hydrostatic pressure, which is an importantly biomechanical property of the intervertebral disc. The current clinical technique for the assessment of intervertebral disc pressure is discography, which is an invasive procedure that has been shown to initiate and exacerbate intervertebral disc degeneration. In this study, we intend to first optimize a protocol to use sodium MRI to measure osmotic pressure in intact intervertebral disc samples. However, due to its low signal-to-noise ratio efficiency, sodium MRI's clinical applicability is limited. In contrast, T1¿ MRI has been shown to be an accurate technique for measuring fixed-charge-density in fibrocartilage such as articular cartilage and intervertebral disc. In addition, since T1¿ targets proton nuclei like conventional MRI techniques, it has comparatively higher signal-to-noise ratio efficiency compared to sodium MRI, which makes it more readily to be applied in clinical setting. Therefore the purpose of this study is to correlate osmotic pressure measured using sodium MRI to T1¿ relaxation time constant of intervertebral discs. In doing so, we can demonstrate T1¿ MRI's clinical utility in the non-invasive measurement of intervertebral disc osmotic pressure.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 椎间盘退变是一种常见且有时使人衰弱的疾病，影响身体健康 占人口的很大比例。椎间盘退变的最早阶段涉及 髓核区域中蛋白多糖的分解和随后的消耗 椎间盘，这会导致椎间盘中的静水压力降低。钠 MRI 此前已 用于计算核组织的固定电荷密度，随后可以 用于计算被钠离子吸引而产生的渗透压 蛋白多糖上带有固定电荷。椎间盘的渗透压与 静水压力，这是椎间盘的一个重要的生物力学特性 光盘。目前临床上评估椎间盘压力的技术是 椎间盘造影，这是一种侵入性手术，已被证明会引发和加剧 椎间盘退变。在这项研究中，我们打算首先优化一个协议来使用 钠 MRI 用于测量完整椎间盘样本的渗透压。然而，由于 由于其信噪比效率较低，钠MRI的临床适用性受到限制。相比之下， T1¿ MRI 已被证明是一种测量固定电荷密度的准确技术 纤维软骨，例如关节软骨和椎间盘。此外，由于 T1¿ 的目标 质子核与传统MRI技术一样，具有相对较高的信噪比 与钠 MRI 相比，其效率更高，这使得它更容易应用于临床环境。 因此，本研究的目的是关联使用钠 MRI 测量的渗透压 至 T1¿ 椎间盘松弛时间常数。这样做，我们可以证明 T1¿ MRI 在无创测量椎间盘渗透压方面的临床应用。