A PROTEIN INTERACTION MAP OF THE BUDDING YEAST SPINDLE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 纺锤体是真核生物细胞分裂过程中分离染色体的复杂机械装置。 复合物的网络包括并调节这种动态结构，以确保染色体遗传的保真度。 在酿酒酵母中，已经鉴定出超过一百种蛋白质在纺锤体功能中起作用。 为了进一步完善我们对这一机制的理解，并确定新的组件，我们与酵母资源中心合作，构建了一个广泛的物理相互作用图的芽殖酵母纺锤体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The spindle is a complex mechanical apparatus that segregates chromosomes during cell division in eukaryotes. A network of complexes comprises and regulates this dynamic structure to ensure fidelity of chromosome inheritance. In Saccharomyces cerevisiae, over one hundred proteins have been identified with a role in spindle function. To further complete our understanding of this mechanism and to identify novel components, we have collaborated with the Yeast Resource Center to construct an extensive physical-interaction map of the budding yeast spindle.