A PROTEIN INTERACTION MAP OF THE BUDDING YEAST SPINDLE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 纺锤体是真核生物细胞分裂过程中分离染色体的一种复杂的机械装置。一个复合体网络组成并调节这种动态结构，以确保染色体遗传的保真度。在酿酒酵母中，已鉴定出100多种与纺锤体功能有关的蛋白质。为了进一步完善我们对这一机制的理解并确定新的成分，我们与酵母资源中心合作构建了一张广泛的发芽酵母纺锤体的物理相互作用图。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The spindle is a complex mechanical apparatus that segregates chromosomes during cell division in eukaryotes. A network of complexes comprises and regulates this dynamic structure to ensure fidelity of chromosome inheritance. In Saccharomyces cerevisiae, over one hundred proteins have been identified with a role in spindle function. To further complete our understanding of this mechanism and to identify novel components, we have collaborated with the Yeast Resource Center to construct an extensive physical-interaction map of the budding yeast spindle.