MAGNETOTACTIC BACTERIA AS A POTENTIAL MRI CONTRAST AGENT

趋磁细菌作为潜在的 MRI 造影剂

• 批准号: 7955383
• 负责人: MICHAEL R BENOIT
• 金额: $ 0.9万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955383
• 关键词: Bacteria; Cancerous; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Funding; Grant; Imagery; Institution; Magnetic Resonance Imaging; Malignant Neoplasms; Nature; Research; Research Personnel; Resources; Source; Technology; United States National Institutes of Health; in vivo; interest; iron oxide; magnetite ferrosoferric oxide; particle; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Magnetotactic bacteria occur naturally and produce chains of magnetite particles, which allow them to align along the Earth's geomagnetic field lines. The magnetite particles are similar to existing iron oxide particles used extensively as contrast agents for MRI enhancement. Due to the microaerophilic nature of magnetotactic bacteria, we reasoned that they may preferentially colonize cancerous tumors, enabling their visualization in vivo using MRI. Although certain bacteria have been known to preferentially colonize cancerous tumors for over 50 years, only recent advances in our understanding of, and ability to manipulate bacteria, have led to a renewed interest in their use for treating cancer.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 磁性细菌自然出现，并产生磁铁矿颗粒的链，从而使它们沿着地球的地磁磁场线对齐。磁铁矿颗粒与现有的氧化铁颗粒相似，广泛用作MRI增强的对比剂。由于磁性细菌的微量微粒性质，我们认为它们可能优先地定居癌性肿瘤，从而可以使用MRI在体内可视化。尽管已知某些细菌优先殖民癌性肿瘤已有50多年的历史，但只有我们对我们对细菌的理解和操纵细菌的能力的最新进展，才引起了人们对治疗癌症使用的新兴趣。