INCORPORATION OF SPIN-LABELED ORGANIC MOLECULES INTO CARBON NANOTUBES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 碳纳米管是碳的同素异形体。它们是由碳原子制成的极薄的中空圆柱体。碳纳米管独特的力学和电学性质使其在纳米技术、电子学、光学和其他材料科学领域具有潜在的应用前景。近年来，它们作为潜在的药物递送剂引起了人们的关注，特别是在癌症治疗方面。肿瘤中的血管泄漏会导致纳米颗粒在肿瘤组织的血流中积聚。了解有机分子在碳纳米管中的掺入和传递有助于设计新的药物和治疗技术。Acert发表了一项关于从微尺度可生物降解微球中控制药物释放的成功研究。研究纳米材料的药物释放将是ESR波谱提供的独特机会的进一步实现，以及ACERT正在开发的新技术，如高分辨率ESR显微镜。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Carbon nanotubes (CNT) are allotropes of carbon. They are extremely thin hollow cylinders made of carbon atoms. Unique mechanical and electrical properties of CNT make them potentially useful in many applications in nanotechnology, electronics, optics and other fields of material science. Recently, they have attracted attention as prospective drug delivery agents, especially in cancer treatment. Leaky blood vessels in tumors cause accumulation of nanoparticles introduced into the bloodstream in the cancerous tissue. Understanding incorporation of organic molecules in carbon nanotubes and delivery of the former can help in designing new drugs and treatment techniques. ACERT published a successful study on control drug release from micro-scale biodegradable microspheres. Studying drug release from nano-materials will be a further implementation of unique opportunities provided by ESR spectroscopy in general and novel technologies being developed in ACERT, such as high resolution ESR microscopy.