INCORPORATION OF SPIN-LABELED ORGANIC MOLECULES INTO CARBON NANOTUBES

将自旋标记有机分子掺入碳纳米管

• 批准号: 8172225
• 负责人: BORIS G DZIKOVSKI
• 金额: $ 0.86万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172225
• 关键词: Attention; Biodegradable microsphere; Blood Circulation; Blood Vessels; Cancerous; Carbon; Carbon Nanotubes; Computer Retrieval of Information on Scientific Projects Database; Drug Controls; Drug Delivery Systems; Electron Spin Resonance Spectroscopy; Electronics; Funding; Grant; Institution; Mechanics; Microscopy; Nanotechnology; Optics; Pharmaceutical Preparations; Publishing; Research; Research Personnel; Resolution; Resources; Science; Source; Spin Labels; Techniques; Tissues; United States National Institutes of Health; cancer therapy; design; electrical property; nanomaterials; nanoparticle; new technology; prospective; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Carbon nanotubes (CNT) are allotropes of carbon. They are extremely thin hollow cylinders made of carbon atoms. Unique mechanical and electrical properties of CNT make them potentially useful in many applications in nanotechnology, electronics, optics and other fields of material science. Recently, they have attracted attention as prospective drug delivery agents, especially in cancer treatment. Leaky blood vessels in tumors cause accumulation of nanoparticles introduced into the bloodstream in the cancerous tissue. Understanding incorporation of organic molecules in carbon nanotubes and delivery of the former can help in designing new drugs and treatment techniques. ACERT published a successful study on control drug release from micro-scale biodegradable microspheres. Studying drug release from nano-materials will be a further implementation of unique opportunities provided by ESR spectroscopy in general and novel technologies being developed in ACERT, such as high resolution ESR microscopy.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 碳纳米管（CNT）是碳的同素异形体。它们是由碳原子制成的极薄的空心圆柱体。碳纳米管独特的机械和电学特性使其在纳米技术、电子、光学和其他材料科学领域的许多应用中具有潜在的用途。最近，它们作为潜在的药物递送剂引起了人们的关注，特别是在癌症治疗中。肿瘤中的血管渗漏会导致进入癌组织血流中的纳米颗粒积聚。了解有机分子在碳纳米管中的掺入以及有机分子的传递有助于设计新药物和治疗技术。 ACERT 发表了一项关于从微型可生物降解微球控制药物释放的成功研究。研究纳米材料的药物释放将进一步利用 ESR 光谱学和 ACERT 正在开发的新技术（例如高分辨率 ESR 显微镜）提供的独特机会。