MAGNETOTACTIC BACTERIA AS A POTENTIAL MRI CONTRAST AGENT

趋磁细菌作为潜在的 MRI 造影剂

• 批准号: 8169857
• 负责人: MICHAEL R BENOIT
• 金额: $ 0.93万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169857
• 关键词: Bacteria; Cancerous; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Funding; Grant; Imagery; Institution; Magnetic Resonance Imaging; Malignant Neoplasms; Nature; Research; Research Personnel; Resources; Source; United States National Institutes of Health; in vivo; interest; iron oxide; magnetite ferrosoferric oxide; particle; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Magnetotactic bacteria occur naturally and produce chains of magnetite particles, which allow them to align along the Earth's geomagnetic field lines. The magnetite particles are similar to existing iron oxide particles used extensively as contrast agents for MRI enhancement. Due to the microaerophilic nature of magnetotactic bacteria, we reasoned that they may preferentially colonize cancerous tumors, enabling their visualization in vivo using MRI. Although certain bacteria have been known to preferentially colonize cancerous tumors for over 50 years, only recent advances in our understanding of, and ability to manipulate bacteria, have led to a renewed interest in their use for treating cancer.

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