QUANTITATIVE INTERROGATION OF IN-VIVO MELANOCYTIC LESIONS USING NEAR INFRARED

使用近红外对体内黑素细胞病变进行定量研究

• 批准号: 7954868
• 负责人: ANTHONY J DURKIN
• 金额: $ 0.19万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954868
• 关键词: Benign; Biological; Biotechnology; Computer Retrieval of Information on Scientific Projects Database; Frequencies; Funding; Grant; Hemoglobin; Image; Institution; Lasers; Lesion; Lighting; Lipids; Malignant - descriptor; Measures; Melanins; Modality; Optics; Pattern; Process; Property; Research; Research Personnel; Resources; Skin; Source; System; Tissues; United States National Institutes of Health; Water; chromophore; in vivo; instrument; novel; optical imaging; skin lesion

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central aim of this project is to develop a novel in-vivo optical skin imaging system to quantitatively characterize changes in skin that accompany dysplastic transformation. The modulated Imaging (MI) instrument uses patterned illumination to non-invasively obtain subsurface images of biological tissues. This non-contact approach enables rapid quantitative determination of the optical properties of tissues over a wide field-of-view. When combined with multi-spectral imaging, the optical properties at several wavelengths provide quantitative measures within tissues to determine the in-vivo concentrations of chromophores, including oxy- and deoxy-hemoglobin, water, lipid and melanin. Furthermore, images at various spatial frequencies can be processed to visualize depth-sectioned subsurface features in terms of scattering and absorption.Our hypothesis is that this multi-modality MI instrument can serve as an imaging platform for quantitative characterization of benign and malignant melanocytic skin lesions.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的主要目的是开发一种新型的体内光学皮肤成像系统，以定量表征伴随发育异常转化的皮肤变化。调制成像（MI）仪器使用图案化照明来非侵入性地获得生物组织的表面下图像。 这种非接触式方法能够在宽视场范围内快速定量测定组织的光学特性。当与多光谱成像相结合时，在几个波长处的光学特性提供组织内的定量测量，以确定发色团的体内浓度，包括氧合血红蛋白和脱氧血红蛋白、水、脂质和黑色素。此外，在不同的空间频率的图像可以被处理，以可视化的散射和absorption. We的假设是，这种多模态MI仪器可以作为一个成像平台的定量表征的良性和恶性黑色素细胞皮肤病变的深度切片的次表面特征。