UNDERGRADUATE RESEARCH PROJECTS IN PROTEIN BIOINFORMATICS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项资助是为在生物信息学领域进行教员支持的独立研究项目的三年级和四年级本科生提供计算机接入。学生将选择一种有生物学意义的蛋白质，最好是其三级结构已经确定的蛋白质。然后，学生将从可用的数据库中获取30-60个蛋白质序列并进行比对。在对路线进行优化后，将进行进化分析。残基和序列基序保守将被用来确定蛋白质的结构和功能关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This grant is to provide computer access for junior and senior undergraduate students performing faculty-supported independent research projects in the field of Bioinformatics. The student will choose a protein of biological interest, preferably one whose tertiary structure has been determined. The student will then procure between 30-60 protein sequences from available databases and align them. Upon optimization of the alignment, evolutionary analysis will be performed. Residue and sequence motif conservation will be used to ellucidate protein structure and function relationships.