UNDERGRADUATE RESEARCH PROJECTS IN PROTEIN BIOINFORMATICS

蛋白质生物信息学本科研究项目

• 批准号: 8171835
• 负责人: JOHN P PEROZICH
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171835
• 关键词: Amino Acid Sequence; Bioinformatics; Biological; Computer Retrieval of Information on Scientific Projects Database; Computers; Databases; Faculty; Funding; Grant; Institution; Peptide Sequence Determination; Proteins; Research; Research Personnel; Research Project Grants; Resources; Source; Structure; Structure-Activity Relationship; Students; United States National Institutes of Health; interest; protein structure function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This grant is to provide computer access for junior and senior undergraduate students performing faculty-supported independent research projects in the field of Bioinformatics. The student will choose a protein of biological interest, preferably one whose tertiary structure has been determined. The student will then procure between 30-60 protein sequences from available databases and align them. Upon optimization of the alignment, evolutionary analysis will be performed. Residue and sequence motif conservation will be used to ellucidate protein structure and function relationships.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项补助金是为在生物信息学领域执行学院支持的独立研究项目的大三和大四本科生提供计算机访问。学生将选择一个生物学感兴趣的蛋白质，最好是一个其三级结构已经确定。然后，学生将从可用的数据库中获取30-60个蛋白质序列并进行比对。在优化比对后，将进行进化分析。残基和序列基序的保守性将用于阐明蛋白质的结构和功能关系。