UNDERGRADUATE RESEARCH PROJECTS IN PROTEIN BIOINFORMATICS

蛋白质生物信息学本科研究项目

• 批准号: 8364258
• 负责人: JOHN P PEROZICH
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364258
• 关键词: Amino Acid Sequence; Bioinformatics; Biological; Biomedical Research; Computers; Databases; Faculty; Funding; Grant; High Performance Computing; National Center for Research Resources; Peptide Sequence Determination; Principal Investigator; Proteins; Research; Research Infrastructure; Research Project Grants; Resources; Source; Structure; Structure-Activity Relationship; Students; United States National Institutes of Health; cost; interest; protein structure function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This grant is to provide computer access for junior and senior undergraduate students performing faculty-supported independent research projects in the field of Bioinformatics. The student will choose a protein of biological interest, preferably one whose tertiary structure has been determined. The student will then procure between 30-60 protein sequences from available databases and align them. Upon optimization of the alignment, evolutionary analysis will be performed. Residue and sequence motif conservation will be used to ellucidate protein structure and function relationships.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项资助是为在生物信息学领域进行教员支持的独立研究项目的三年级和四年级本科生提供计算机接入。学生将选择一种有生物学意义的蛋白质，最好是其三级结构已经确定的蛋白质。然后，学生将从可用的数据库中获取30-60个蛋白质序列并进行比对。在对路线进行优化后，将进行进化分析。残基和序列基序保守将被用来确定蛋白质的结构和功能关系。