TRANSIENT RECEPTOR POTENTIAL VANILLOID 6 (TRPV6) ANKYRIN REPEAT DOMAIN

瞬时受体电位香草酸 6 (TRPV6) 锚蛋白重复结构域

• 批准号: 7955140
• 负责人: RACHELLE GAUDET
• 金额: $ 0.81万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955140
• 关键词: Ankyrin Repeat; Biochemical; C-terminal; Calcium; Cations; Computer Retrieval of Information on Scientific Projects Database; Cytoplasmic Tail; Family; Funding; Grant; Homeostasis; Institution; N-terminal; Property; Proteins; Regulation; Research; Research Personnel; Resources; Source; Structure; TRPV channel; TRPV1 gene; Transmembrane Domain; United States National Institutes of Health; Vanilloid; member; receptor; structural biology; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Transient receptor potential (TRP) proteins are cation channels composed of a transmembrane domain flanked by large N- and C-terminal cytoplasmic domains. All members of the vanilloid family of TRP channels (TRPV) possess an N-terminal ankyrin repeat domain (ARD). The ARD of mammalian TRPV6, an important regulator of calcium uptake and homeostasis, is essential for channel assembly and regulation. Determining the structure of the TRPV6-ARD will allow us to compare its structure and biochemical properties to those of the TRPV1 and TRPV2 proteins previously determined in our lab.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 瞬时受体电位(Trp)蛋白是由跨膜区和大的N-末端和C-末端胞质结构域组成的阳离子通道。香草型Trp通道家族(TRPV)的所有成员都有一个N-末端的Ankyrin重复结构域(ARD)。哺乳动物TRPV6的ARD是钙摄取和稳态的重要调节因子，对通道的组装和调节是必不可少的。确定TRPV6-ARD的结构将使我们能够将其结构和生化性质与我们实验室先前确定的TRPV1和TRPV2蛋白进行比较。